biostudies-literatureUnknown13(1)Di Rosa MColorectal Cancer (CRC) is one of the most common cancers accounting for 1.8 million new cases worldwide every year. Therefore, the identification of new potential therapeutic targets represents a continuous challenge to improve survival and quality of CRC patient's life. We performed a microarray analysis dataset consisting of colon biopsies of healthy subjects (HS) and CRC patients. These results were further confirmed in a clinical setting evaluating a series of CRC patients to assess the expression of Resistin-Like Beta (RETNLB) and to correlate it with their clinical data. Our results showed a significant reduction of RETNLB expression in CRC biopsies compared to the HS mucosa. Furthermore, such reduction was significantly associated with the TNM grade and patients' age. Furthermore, Scientific reports1490https://www.ebi.ac.uk/biostudies/studies/S-EPMC9883247biostudies-literatureResistin-like beta reduction is associated to low survival rate and is downregulated by adjuvant therapy in colorectal cancer patients.PMC9883247Castrogiovanni PSalomone FDi Cataldo ACaltabiano RImbesi RLi Volti GLanteri RTibullo DBroggi GRaciti GDi Rosa MfalseResistin-like beta reduction is associated to low survival rate and is downregulated by adjuvant therapy in colorectal cancer patients.Colorectal Cancer (CRC) is one of the most common cancers accounting for 1.8 million new cases worldwide every year. Therefore, the identification of new potential therapeutic targets represents a continuous challenge to improve survival and quality of CRC patient's life. We performed a microarray analysis dataset consisting of colon biopsies of healthy subjects (HS) and CRC patients. These results were further confirmed in a clinical setting evaluating a series of CRC patients to assess the expression of Resistin-Like Beta (RETNLB) and to correlate it with their clinical data. Our results showed a significant reduction of RETNLB expression in CRC biopsies compared to the HS mucosa. Furthermore, such reduction was significantly associated with the TNM grade and patients' age. Furthermore, 2023-01-01T00:00:00Z2023 Jan2026-06-21T03:17:41.733Z2026-06-21T03:11:27.072ZS-EPMC98832473670769810.1038/s41598-023-28450-1