biostudies-literatureEick SMU.S. Environmental Protection AgencyNIEHS NIH HHSNIMHD NIH HHSNINR NIH HHSNational Institutes of HealthNIH HHS159450https://www.ebi.ac.uk/biostudies/studies/S-EPMC9884463biostudies-literatureUnknown857(Pt 2)<h4>Background</h4>African Americans (AAs) experience high rates of adverse pregnancy outcomes relative to Whites. Differential in utero exposure to environmental chemicals and psychosocial stressors may explain some of the observed health disparities, as exposures to per- and polyfluoroalkyl substances (PFAS) and experiences of discrimination have been linked to adverse birth outcomes. Few studies have examined chemicals and non-chemical stressors together as an exposure mixture, which may better reflect real-life exposure patterns. Here, we adapted methods designed for the analysis of exposure mixtures to examine joint effects of PFAS and psychosocial stress on birth outcomes among AAs.<h4>Methods</h4>348 participants from the Atlanta African American Maternal-Child cohort were included The Science of the total environmentPer- and polyfluoroalkyl substances and psychosocial stressors have a joint effect on adverse pregnancy outcomes in the Atlanta African American Maternal-Child cohort.PMC9884463P50ES02607U2C ES026542UG3/UH3OD023318P30ES019776R01MD009746UG3 OD023318U2C ES02656083615301R01 NR014800U2CES026560R24 ES029490R01 MD009746R24ES029490P30 ES019776U2COD023375R01NR014800R01MD009064R01 MD009064U2CES026542U2C OD023375UH3 OD023318Eick SMLiang DYakimavets VBarr DBTaibl KRBrennan PARobinson MDunlop ALTan YKannan KPanuwet PRyan PBfalsePer- and polyfluoroalkyl substances and psychosocial stressors have a joint effect on adverse pregnancy outcomes in the Atlanta African American Maternal-Child cohort.<h4>Background</h4>African Americans (AAs) experience high rates of adverse pregnancy outcomes relative to Whites. Differential in utero exposure to environmental chemicals and psychosocial stressors may explain some of the observed health disparities, as exposures to per- and polyfluoroalkyl substances (PFAS) and experiences of discrimination have been linked to adverse birth outcomes. Few studies have examined chemicals and non-chemical stressors together as an exposure mixture, which may better reflect real-life exposure patterns. Here, we adapted methods designed for the analysis of exposure mixtures to examine joint effects of PFAS and psychosocial stress on birth outcomes among AAs.<h4>Methods</h4>348 participants from the Atlanta African American Maternal-Child cohort were included 2023-01-01T00:00:00Z2023 Jan2025-04-03T23:51:31.337Z2025-04-03T23:51:31.337ZS-EPMC98844633625267210.1016/j.scitotenv.2022.159450