{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["36"],"submitter":["Tanaka S"],"pubmed_abstract":["High-density lipoproteins (HDLs), whose main role is the reverse transport of cholesterol, also have pleiotropic anti-inflammatory, antioxidant, anti-apoptotic and anti-infectious properties. During sepsis, HDL cholesterol (HDL-C) concentration is low, HDL particle functionality is altered, and these modifications are correlated with poor outcomes. Based on the protective effects of HDL, we hypothesized that HDL-C levels could be associated with lung transplantation (LT) outcome. We thus looked for an association between basal HDL-C concentration and one-year mortality after LT. In this single-center prospective study including consecutive LTs from 2015 to 2020, 215 patients were included, essentially pulmonary fibrosis (47%) and chronic obstructive pulmonary disease (COPD) (38%) patients."],"journal":["Transplant international : official journal of the European Society for Organ Transplantation"],"pagination":["10841"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9884674"],"repository":["biostudies-literature"],"pubmed_title":["Low HDL-Cholesterol Concentrations in Lung Transplant Candidates are Strongly Associated With One-Year Mortality After Lung Transplantation."],"pmcid":["PMC9884674"],"pubmed_authors":["Medraoui C","Castier Y","Kantor E","Cerceau P","Senemaud J","Weisenburger G","Bunel V","Mouren D","Labed P","Mal H","Mignon A","Mordant P","Jean-Baptiste S","Sandrine Boudinet LC","Frere G","Tanaka S","Longrois D","Tymowski C","de Menonville CT","Ben-Rehouma M","Tissot S","Godet C","Montravers P","Renard R","Messika J","Atchade E","Ferreira D","Salpin M","Lortat-Jacob B","Robert T","Abadie A","Jebrak G","Savary A","Roussel A","Tran-Dinh A","Zappella N","Bichat Lung Transplant Group","Marceau A","Tashk P","Meilhac O","Goletto T","de Tymowski C","Stern J","Snauwert A","Genet L","Trigueiros S","Pellenc Q"],"additional_accession":[]},"is_claimable":false,"name":"Low HDL-Cholesterol Concentrations in Lung Transplant Candidates are Strongly Associated With One-Year Mortality After Lung Transplantation.","description":"High-density lipoproteins (HDLs), whose main role is the reverse transport of cholesterol, also have pleiotropic anti-inflammatory, antioxidant, anti-apoptotic and anti-infectious properties. During sepsis, HDL cholesterol (HDL-C) concentration is low, HDL particle functionality is altered, and these modifications are correlated with poor outcomes. Based on the protective effects of HDL, we hypothesized that HDL-C levels could be associated with lung transplantation (LT) outcome. We thus looked for an association between basal HDL-C concentration and one-year mortality after LT. In this single-center prospective study including consecutive LTs from 2015 to 2020, 215 patients were included, essentially pulmonary fibrosis (47%) and chronic obstructive pulmonary disease (COPD) (38%) patients.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-04-26T18:11:22.094Z","creation":"2025-04-06T15:43:07.569Z"},"accession":"S-EPMC9884674","cross_references":{"pubmed":["36726695"],"doi":["10.3389/ti.2023.10841"]}}