biostudies-literatureUnknown36Tanaka SHigh-density lipoproteins (HDLs), whose main role is the reverse transport of cholesterol, also have pleiotropic anti-inflammatory, antioxidant, anti-apoptotic and anti-infectious properties. During sepsis, HDL cholesterol (HDL-C) concentration is low, HDL particle functionality is altered, and these modifications are correlated with poor outcomes. Based on the protective effects of HDL, we hypothesized that HDL-C levels could be associated with lung transplantation (LT) outcome. We thus looked for an association between basal HDL-C concentration and one-year mortality after LT. In this single-center prospective study including consecutive LTs from 2015 to 2020, 215 patients were included, essentially pulmonary fibrosis (47%) and chronic obstructive pulmonary disease (COPD) (38%) patients.Transplant international : official journal of the European Society for Organ Transplantation10841https://www.ebi.ac.uk/biostudies/studies/S-EPMC9884674biostudies-literatureLow HDL-Cholesterol Concentrations in Lung Transplant Candidates are Strongly Associated With One-Year Mortality After Lung Transplantation.PMC9884674Medraoui CCastier YKantor ECerceau PSenemaud JWeisenburger GBunel VMouren DLabed PMal HMignon AMordant PJean-Baptiste SSandrine Boudinet LCFrere GTanaka SLongrois DTymowski Cde Menonville CTBen-Rehouma MTissot SGodet CMontravers PRenard RMessika JAtchade EFerreira DSalpin MLortat-Jacob BRobert TAbadie AJebrak GSavary ARoussel ATran-Dinh AZappella NBichat Lung Transplant GroupMarceau ATashk PMeilhac OGoletto Tde Tymowski CStern JSnauwert AGenet LTrigueiros SPellenc QfalseLow HDL-Cholesterol Concentrations in Lung Transplant Candidates are Strongly Associated With One-Year Mortality After Lung Transplantation.High-density lipoproteins (HDLs), whose main role is the reverse transport of cholesterol, also have pleiotropic anti-inflammatory, antioxidant, anti-apoptotic and anti-infectious properties. During sepsis, HDL cholesterol (HDL-C) concentration is low, HDL particle functionality is altered, and these modifications are correlated with poor outcomes. Based on the protective effects of HDL, we hypothesized that HDL-C levels could be associated with lung transplantation (LT) outcome. We thus looked for an association between basal HDL-C concentration and one-year mortality after LT. In this single-center prospective study including consecutive LTs from 2015 to 2020, 215 patients were included, essentially pulmonary fibrosis (47%) and chronic obstructive pulmonary disease (COPD) (38%) patients.2023-01-01T00:00:00Z20232025-04-26T18:11:22.094Z2025-04-06T15:43:07.569ZS-EPMC98846743672669510.3389/ti.2023.10841