biostudies-literatureUnknown24(10)Ho TJH<h4>Objective</h4>Schools offer an ideal setting for childhood obesity interventions due to their access to children and adolescents. This review aimed to systematically review the impact of school-based intervention for the treatment of childhood obesity.<h4>Design</h4>Eight databases were searched from inception till 30 May 2020. A revised Cochrane risk-of-bias tool and the Grading of Recommendations, Assessment, Development and Evaluations criteria were used to evaluate the risk of bias and overall evidence. Meta-analysis and meta-regression were performed on Stata software using the random effects model. Overall effect was evaluated using Hedges' g, and heterogeneity was assessed using Cochran's Q and I2.<h4>Setting</h4>Cluster randomised controlled trials (cluster-RCT) delivered in scPublic health nutrition3087-3099https://www.ebi.ac.uk/biostudies/studies/S-EPMC9884753biostudies-literatureSchool-based interventions for the treatment of childhood obesity: a systematic review, meta-analysis and meta-regression of cluster randomised controlled trials.PMC9884753Ho TJHLau YCheng LJfalseSchool-based interventions for the treatment of childhood obesity: a systematic review, meta-analysis and meta-regression of cluster randomised controlled trials.<h4>Objective</h4>Schools offer an ideal setting for childhood obesity interventions due to their access to children and adolescents. This review aimed to systematically review the impact of school-based intervention for the treatment of childhood obesity.<h4>Design</h4>Eight databases were searched from inception till 30 May 2020. A revised Cochrane risk-of-bias tool and the Grading of Recommendations, Assessment, Development and Evaluations criteria were used to evaluate the risk of bias and overall evidence. Meta-analysis and meta-regression were performed on Stata software using the random effects model. Overall effect was evaluated using Hedges' g, and heterogeneity was assessed using Cochran's Q and I2.<h4>Setting</h4>Cluster randomised controlled trials (cluster-RCT) delivered in sc2021-01-01T00:00:00Z2021 Jul2026-03-15T16:08:34.103Z2025-04-05T17:07:06.333ZS-EPMC98847533374550110.1017/s136898002100111710.1017/S1368980021001117