{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["69(12)"],"submitter":["Oguariri RM"],"pubmed_abstract":["We used a panel of nine fusion proteins that contain different Duffy binding-like alpha (DBL-alpha) domains of Plasmodium falciparum-infected erythrocyte membrane protein 1 to assess the levels of antibody activity in serum samples obtained from semi-immune or nonimmune individuals from Lambaréné, Gabon. Recognition was measured in terms of either the prevalence or the magnitude of the response. A strong correlation between the immune status of the patients and reactivity with recombinant proteins was observed, which was interpreted as a reflection of the number of infections acquired over time. The antibody responses were predominantly directed toward variable epitopes of the DBL-alpha domain. Antibody responses could be reduced by preincubation of the sera with various fusion proteins. A"],"journal":["Infection and immunity"],"pagination":["7603-9"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC98853"],"repository":["biostudies-literature"],"pubmed_title":["High prevalence of human antibodies to recombinant Duffy binding-like alpha domains of the Plasmodium falciparum-infected erythrocyte membrane protein 1 in semi-immune adults compared to that in nonimmune children."],"pmcid":["PMC98853"],"pubmed_authors":["Borrmann S","Kun JF","Kremsner PG","Oguariri RM","Klinkert MQ"],"additional_accession":[]},"is_claimable":false,"name":"High prevalence of human antibodies to recombinant Duffy binding-like alpha domains of the Plasmodium falciparum-infected erythrocyte membrane protein 1 in semi-immune adults compared to that in nonimmune children.","description":"We used a panel of nine fusion proteins that contain different Duffy binding-like alpha (DBL-alpha) domains of Plasmodium falciparum-infected erythrocyte membrane protein 1 to assess the levels of antibody activity in serum samples obtained from semi-immune or nonimmune individuals from Lambaréné, Gabon. Recognition was measured in terms of either the prevalence or the magnitude of the response. A strong correlation between the immune status of the patients and reactivity with recombinant proteins was observed, which was interpreted as a reflection of the number of infections acquired over time. The antibody responses were predominantly directed toward variable epitopes of the DBL-alpha domain. Antibody responses could be reduced by preincubation of the sera with various fusion proteins. A","dates":{"release":"2001-01-01T00:00:00Z","publication":"2001 Dec","modification":"2025-04-19T08:53:14.494Z","creation":"2019-03-27T00:16:48Z"},"accession":"S-EPMC98853","cross_references":{"pubmed":["11705939"],"doi":["10.1128/iai.69.12.7603-7609.2001","10.1128/IAI.69.12.7603-7609.2001"]}}