{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["45(2)"],"submitter":["Wong CHY"],"funding":["Peter T. C. Lee Endowed Chair Professorship","Wuxi Municipal Office of Talent Affairs"],"pubmed_abstract":["Age-related cognitive slowing is a prominent precursor of cognitive decline. Functional neuroimaging studies found that cognitive processing speed is associated with activation and coupling among frontal, parietal and cerebellar brain networks. However, how the reciprocal influences of inter- and intra-network coupling mediate age-related decline in processing speed remains insufficiently studied. This study examined how inter- and intra-brain network influences mediate age-related slowing. We were interested in the fronto-insular salience network (SN), frontoparietal dorsal attention network (DAN), cerebellar network (CN) and default mode network (DMN). Reaction time (RT) and functional MRI data from 84 participants (aged 18-75) were collected while they were performing the Arrow Task in "],"journal":["GeroScience"],"pagination":["889-899"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9886783"],"repository":["biostudies-literature"],"pubmed_title":["Causal influences of salience/cerebellar networks on dorsal attention network subserved age-related cognitive slowing."],"pmcid":["PMC9886783"],"pubmed_authors":["Yuan HL","Chan CCH","Tao J","Chen LD","Wong MNK","Liu J","Lee TMC","Xu YW","Wong CHY"],"additional_accession":[]},"is_claimable":false,"name":"Causal influences of salience/cerebellar networks on dorsal attention network subserved age-related cognitive slowing.","description":"Age-related cognitive slowing is a prominent precursor of cognitive decline. Functional neuroimaging studies found that cognitive processing speed is associated with activation and coupling among frontal, parietal and cerebellar brain networks. However, how the reciprocal influences of inter- and intra-network coupling mediate age-related decline in processing speed remains insufficiently studied. This study examined how inter- and intra-brain network influences mediate age-related slowing. We were interested in the fronto-insular salience network (SN), frontoparietal dorsal attention network (DAN), cerebellar network (CN) and default mode network (DMN). Reaction time (RT) and functional MRI data from 84 participants (aged 18-75) were collected while they were performing the Arrow Task in ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2026-07-09T12:26:01.542Z","creation":"2025-04-19T03:52:05.723Z"},"accession":"S-EPMC9886783","cross_references":{"pubmed":["36401740"],"doi":["10.1007/s11357-022-00686-1"]}}