{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(1)"],"submitter":["Tunganuntarat J"],"pubmed_abstract":["Autophagy induction by starvation has been shown to enhance lysosomal delivery to mycobacterial phagosomes, resulting in the restriction of the Mycobacterium tuberculosis reference strain H37Rv. In contrast to H37Rv, our previous study showed that strains belonging to the notorious M. tuberculosis Beijing genotype could evade autophagic elimination. Our recent RNA-Seq analysis also discovered that the autophagy-resistant M. tuberculosis Beijing strain (BJN) evaded autophagic control by upregulating the expression of Kxd1, a BORC complex component, and Plekhm2, both of which function in lysosome positioning towards the cell periphery in host macrophages, thereby suppressing enhanced lysosomal delivery to its phagosome and sparing the BJN from elimination as a result. In this work, we furthe"],"journal":["Scientific reports"],"pagination":["1663"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9886903"],"repository":["biostudies-literature"],"pubmed_title":["BORC complex specific components and Kinesin-1 mediate autophagy evasion by the autophagy-resistant Mycobacterium tuberculosis Beijing strain."],"pmcid":["PMC9886903"],"pubmed_authors":["Khumpanied T","Siregar TAP","Kanjanasirirat P","Palittapongarnpim P","Ponpuak M","Chaiprasert A","Benjaskulluecha S","Palaga T","Wongprom B","Borwornpinyo S","Tunganuntarat J"],"additional_accession":[]},"is_claimable":false,"name":"BORC complex specific components and Kinesin-1 mediate autophagy evasion by the autophagy-resistant Mycobacterium tuberculosis Beijing strain.","description":"Autophagy induction by starvation has been shown to enhance lysosomal delivery to mycobacterial phagosomes, resulting in the restriction of the Mycobacterium tuberculosis reference strain H37Rv. In contrast to H37Rv, our previous study showed that strains belonging to the notorious M. tuberculosis Beijing genotype could evade autophagic elimination. Our recent RNA-Seq analysis also discovered that the autophagy-resistant M. tuberculosis Beijing strain (BJN) evaded autophagic control by upregulating the expression of Kxd1, a BORC complex component, and Plekhm2, both of which function in lysosome positioning towards the cell periphery in host macrophages, thereby suppressing enhanced lysosomal delivery to its phagosome and sparing the BJN from elimination as a result. In this work, we furthe","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-05T16:07:15.868Z","creation":"2025-04-05T16:07:15.868Z"},"accession":"S-EPMC9886903","cross_references":{"pubmed":["36717601"],"doi":["10.1038/s41598-023-28983-5"]}}