biostudies-literatureUnknown9Grimaldi MC<h4>Background</h4>The tricuspid annular plane systolic excursion/systolic pulmonary arterial pressure (TAPSE/sPAP) ratio is an echocardiographic estimation of the right ventricle to pulmonary artery (RV/PA) coupling, with a validated prognostic role in different clinical settings. Systemic sclerosis (SSc) patients without evident cardiovascular involvement frequently display subtle RV impairment. The amino-terminal atrial natriuretic peptide (NT-proANP) plasma level relates to SSc disease progression and mortality. We aimed to assess the prognostic value of the TAPSE/sPAP ratio and its relationship with NT-proANP plasma level in SSc patients without overt cardiovascular involvement.<h4>Methods</h4>We retrospectively analysed 70 SSc consecutive patients, with no clinical evidence of cardioFrontiers in cardiovascular medicine1021048https://www.ebi.ac.uk/biostudies/studies/S-EPMC9887033biostudies-literatureThe prognostic role of the echocardiographic tricuspid annular plane systolic excursion/systolic pulmonary arterial pressure (TAPSE/sPAP) ratio and its relationship with NT-proANP plasma level in systemic sclerosis.PMC9887033Rubattu SRosato ERomaniello AGrimaldi MCCristiano EVolpe MD'Angelo AMarchitti SfalseThe prognostic role of the echocardiographic tricuspid annular plane systolic excursion/systolic pulmonary arterial pressure (TAPSE/sPAP) ratio and its relationship with NT-proANP plasma level in systemic sclerosis.<h4>Background</h4>The tricuspid annular plane systolic excursion/systolic pulmonary arterial pressure (TAPSE/sPAP) ratio is an echocardiographic estimation of the right ventricle to pulmonary artery (RV/PA) coupling, with a validated prognostic role in different clinical settings. Systemic sclerosis (SSc) patients without evident cardiovascular involvement frequently display subtle RV impairment. The amino-terminal atrial natriuretic peptide (NT-proANP) plasma level relates to SSc disease progression and mortality. We aimed to assess the prognostic value of the TAPSE/sPAP ratio and its relationship with NT-proANP plasma level in SSc patients without overt cardiovascular involvement.<h4>Methods</h4>We retrospectively analysed 70 SSc consecutive patients, with no clinical evidence of cardio2022-01-01T00:00:00Z20222025-04-22T18:09:58.431Z2025-04-06T02:23:27.971ZS-EPMC98870333673382910.3389/fcvm.2022.1021048