{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["De Falco E"],"funding":["Sapienza Università di Roma"],"pagination":["1011063"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9889152"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2023"],"pubmed_abstract":["Cancer alters both local and distant tissue by influencing the microenvironment. In this regard, the interplay with the stromal fraction is considered critical as this latter can either foster or hamper the progression of the disease. Accordingly, the modality by which tumors may alter distant niches of stromal cells is still unclear, especially at early stages. In this short report, we attempt to better understand the biology of this cross-talk. In our \"autologous stromal experimental setting,\" we found that remote adipose tissue-derived mesenchymal stem cells (mediastinal AMSC) obtained from patients with lung adenocarcinoma sustain proliferation and clonogenic ability of A549 and human primary lung adenocarcinoma cells similarly to the autologous stromal lung counterpart (LMSC). This ef"],"journal":["Journal of oncology"],"pubmed_title":["Remote Adipose Tissue-Derived Stromal Cells of Patients with Lung Adenocarcinoma Generate a Similar Malignant Microenvironment of the Lung Stromal Counterpart."],"pmcid":["PMC9889152"],"funding_grant_id":["C26A13SC2R","AR22218167F02218"],"pubmed_authors":["De Falco E","De Marinis E","Maria Giorgiano N","Rosa P","Picchio V","Dhori X","Floris E","Angelo Rendina E","Menna C","Bordin A","Calogero A","Cozzolino C","Ibrahim M"],"additional_accession":[]},"is_claimable":false,"name":"Remote Adipose Tissue-Derived Stromal Cells of Patients with Lung Adenocarcinoma Generate a Similar Malignant Microenvironment of the Lung Stromal Counterpart.","description":"Cancer alters both local and distant tissue by influencing the microenvironment. In this regard, the interplay with the stromal fraction is considered critical as this latter can either foster or hamper the progression of the disease. Accordingly, the modality by which tumors may alter distant niches of stromal cells is still unclear, especially at early stages. In this short report, we attempt to better understand the biology of this cross-talk. In our \"autologous stromal experimental setting,\" we found that remote adipose tissue-derived mesenchymal stem cells (mediastinal AMSC) obtained from patients with lung adenocarcinoma sustain proliferation and clonogenic ability of A549 and human primary lung adenocarcinoma cells similarly to the autologous stromal lung counterpart (LMSC). This ef","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-08-12T03:05:07.146Z","creation":"2025-04-06T02:23:47.658Z"},"accession":"S-EPMC9889152","cross_references":{"pubmed":["36733673"],"doi":["10.1155/2023/1011063"]}}