{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(1)"],"submitter":["Romani C"],"pubmed_abstract":["Adenoid cystic carcinoma (ACC) of salivary gland is a slowly growing tumor showing a propensity for delayed recurrence, with decreased survival rates. The identification of poor prognosis patients may help in defining molecular-based targeted strategies in this rare disease orphan of new treatments. Through a gene expression microarray-based approach followed by GSE functional analysis the expression profile of 46 primary untreated ACC samples and of ACC (h-TERT) tumor cells was analyzed. Patients who experienced early relapse showed enrichment in proliferation-related gene sets, including the G2-M checkpoint, E2F and myc targets, and in gene sets related to IFN signaling and aberrant proteostasis (FDR < 0.1), indicating increased mitotic and transcriptional activity in aggressive ACC. Sim"],"journal":["Scientific reports"],"pagination":["1809"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9889376"],"repository":["biostudies-literature"],"pubmed_title":["Functional profiles of curatively treated adenoid cystic carcinoma unveil prognostic features and potentially targetable pathways."],"pmcid":["PMC9889376"],"pubmed_authors":["Bossi P","Bozzola A","Bignotti E","Bugatti M","Lombardi D","Ravaggi A","Ardighieri L","Romani C","Lorini L","Battocchio S","Ravanelli M","Gurizzan C","Calza S","Tomasoni M","Tomasini D","Mattavelli D","Piazza C"],"additional_accession":[]},"is_claimable":false,"name":"Functional profiles of curatively treated adenoid cystic carcinoma unveil prognostic features and potentially targetable pathways.","description":"Adenoid cystic carcinoma (ACC) of salivary gland is a slowly growing tumor showing a propensity for delayed recurrence, with decreased survival rates. The identification of poor prognosis patients may help in defining molecular-based targeted strategies in this rare disease orphan of new treatments. Through a gene expression microarray-based approach followed by GSE functional analysis the expression profile of 46 primary untreated ACC samples and of ACC (h-TERT) tumor cells was analyzed. Patients who experienced early relapse showed enrichment in proliferation-related gene sets, including the G2-M checkpoint, E2F and myc targets, and in gene sets related to IFN signaling and aberrant proteostasis (FDR < 0.1), indicating increased mitotic and transcriptional activity in aggressive ACC. Sim","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-06T19:15:08.718Z","creation":"2025-04-06T19:15:08.718Z"},"accession":"S-EPMC9889376","cross_references":{"pubmed":["36720951"],"doi":["10.1038/s41598-023-28901-9"]}}