biostudies-literatureUnknown13(1)Romani CAdenoid cystic carcinoma (ACC) of salivary gland is a slowly growing tumor showing a propensity for delayed recurrence, with decreased survival rates. The identification of poor prognosis patients may help in defining molecular-based targeted strategies in this rare disease orphan of new treatments. Through a gene expression microarray-based approach followed by GSE functional analysis the expression profile of 46 primary untreated ACC samples and of ACC (h-TERT) tumor cells was analyzed. Patients who experienced early relapse showed enrichment in proliferation-related gene sets, including the G2-M checkpoint, E2F and myc targets, and in gene sets related to IFN signaling and aberrant proteostasis (FDR < 0.1), indicating increased mitotic and transcriptional activity in aggressive ACC. SimScientific reports1809https://www.ebi.ac.uk/biostudies/studies/S-EPMC9889376biostudies-literatureFunctional profiles of curatively treated adenoid cystic carcinoma unveil prognostic features and potentially targetable pathways.PMC9889376Bossi PBozzola ABignotti EBugatti MLombardi DRavaggi AArdighieri LRomani CLorini LBattocchio SRavanelli MGurizzan CCalza STomasoni MTomasini DMattavelli DPiazza CfalseFunctional profiles of curatively treated adenoid cystic carcinoma unveil prognostic features and potentially targetable pathways.Adenoid cystic carcinoma (ACC) of salivary gland is a slowly growing tumor showing a propensity for delayed recurrence, with decreased survival rates. The identification of poor prognosis patients may help in defining molecular-based targeted strategies in this rare disease orphan of new treatments. Through a gene expression microarray-based approach followed by GSE functional analysis the expression profile of 46 primary untreated ACC samples and of ACC (h-TERT) tumor cells was analyzed. Patients who experienced early relapse showed enrichment in proliferation-related gene sets, including the G2-M checkpoint, E2F and myc targets, and in gene sets related to IFN signaling and aberrant proteostasis (FDR < 0.1), indicating increased mitotic and transcriptional activity in aggressive ACC. Sim2023-01-01T00:00:00Z2023 Jan2025-04-06T19:15:08.718Z2025-04-06T19:15:08.718ZS-EPMC98893763672095110.1038/s41598-023-28901-9