biostudies-literatureKim HJKorea Disease Control and Prevention Agency1786https://www.ebi.ac.uk/biostudies/studies/S-EPMC9889397biostudies-literatureUnknown13(1)This study aimed to evaluate changes in health-related quality of life (HRQOL) in patients with chronic kidney disease (CKD) according to decline in kidney function. HRQOL was assessed using the Short Form-36 questionnaire composed of a physical component summary (PCS) and mental component summary (MCS). Rapid decline in kidney function was defined as a decline in the estimated glomerular filtration rate (eGFR) of > 3 mL/min/1.73 m²/year. Rapid deterioration of HRQOL was defined a change in the HRQOL value greater than the median. Among 970 patients, 360 (37.1%) were in the rapid kidney function decline group. In 720 patients who were 1:1 propensity score-matched, the baseline eGFR was not significantly different between the non-rapid and rapid kidney function decline groups. CoScientific reportsRapid decline in kidney function is associated with rapid deterioration of health-related quality of life in chronic kidney disease.PMC98893972011E3300300, 2012E3301100, 2013E3301600, 2013E3301601, 2013E3301602, 2016E3300200, 2016E3300201, 2016E3300202, 2019E320100, 2019E320101, 2019E320102, and 2022-11-007Kim SWSeong EYKim DWKim YHKim HJRhee HSung SSong SHOh KHPark SKfalseRapid decline in kidney function is associated with rapid deterioration of health-related quality of life in chronic kidney disease.This study aimed to evaluate changes in health-related quality of life (HRQOL) in patients with chronic kidney disease (CKD) according to decline in kidney function. HRQOL was assessed using the Short Form-36 questionnaire composed of a physical component summary (PCS) and mental component summary (MCS). Rapid decline in kidney function was defined as a decline in the estimated glomerular filtration rate (eGFR) of > 3 mL/min/1.73 m²/year. Rapid deterioration of HRQOL was defined a change in the HRQOL value greater than the median. Among 970 patients, 360 (37.1%) were in the rapid kidney function decline group. In 720 patients who were 1:1 propensity score-matched, the baseline eGFR was not significantly different between the non-rapid and rapid kidney function decline groups. Co2023-01-01T00:00:00Z2023 Jan2026-07-09T12:22:35.442Z2025-04-06T19:15:11.688ZS-EPMC98893973672096910.1038/s41598-023-28150-w