biostudies-literatureKolosowska KInstitute of Psychiatry and Neurology, WarsawNarodowe Centrum Nauki85-98https://www.ebi.ac.uk/biostudies/studies/S-EPMC9889529biostudies-literatureUnknown75(1)<h4>Background</h4>Long-term cocaine exposure leads to dysregulation of the reward system and initiates processes that ultimately weaken its rewarding effects. Here, we studied the influence of an escalating-dose cocaine regimen on drug-associated appetitive behavior after a withdrawal period, along with corresponding molecular changes in plasma and the prefrontal cortex (PFC).<h4>Methods</h4>We applied a 5 day escalating-dose cocaine regimen in rats. We assessed anxiety-like behavior at the beginning of the withdrawal period in the elevated plus maze (EPM) test. The reinforcement properties of cocaine were evaluated in the Conditioned Place Preference (CPP) test along with ultrasonic vocalization (USV) in the appetitive range in a drug-associated context. We assessed corticosterone, proopPharmacological reports : PRMolecular pattern of a decrease in the rewarding effect of cocaine after an escalating-dose drug regimen.PMC98895292018/28/C/NZ7/00240501-40003-18017Sobolewska ASkorzewska ABednarska-Makaruk MLiguz-Lecznar MLehner MMaciejak PWislowska-Stanek AKolosowska KGawryluk ATomczuk FTurzynska DfalseMolecular pattern of a decrease in the rewarding effect of cocaine after an escalating-dose drug regimen.<h4>Background</h4>Long-term cocaine exposure leads to dysregulation of the reward system and initiates processes that ultimately weaken its rewarding effects. Here, we studied the influence of an escalating-dose cocaine regimen on drug-associated appetitive behavior after a withdrawal period, along with corresponding molecular changes in plasma and the prefrontal cortex (PFC).<h4>Methods</h4>We applied a 5 day escalating-dose cocaine regimen in rats. We assessed anxiety-like behavior at the beginning of the withdrawal period in the elevated plus maze (EPM) test. The reinforcement properties of cocaine were evaluated in the Conditioned Place Preference (CPP) test along with ultrasonic vocalization (USV) in the appetitive range in a drug-associated context. We assessed corticosterone, proop2023-01-01T00:00:00Z2023 Feb2025-04-22T04:02:03.658Z2025-04-05T20:51:29.456ZS-EPMC98895293658607510.1007/s43440-022-00443-3