{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Buchanan J"],"funding":["HHS | National Institutes of Health","NEI NIH HHS","NIA NIH HHS","NIMH NIH HHS","HHS | NIH | National Institute of Neurological Disorders and Stroke","DNI | Intelligence Advanced Research Projects Activity","NINDS NIH HHS"],"pagination":["e2202580119"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9889886"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["119(48)"],"pubmed_abstract":["Neurons in the developing brain undergo extensive structural refinement as nascent circuits adopt their mature form. This physical transformation of neurons is facilitated by the engulfment and degradation of axonal branches and synapses by surrounding glial cells, including microglia and astrocytes. However, the small size of phagocytic organelles and the complex, highly ramified morphology of glia have made it difficult to define the contribution of these and other glial cell types to this crucial process. Here, we used large-scale, serial section transmission electron microscopy (TEM) with computational volume segmentation to reconstruct the complete 3D morphologies of distinct glial types in the mouse visual cortex, providing unprecedented resolution of their morphology and composition"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Oligodendrocyte precursor cells ingest axons in the mouse neocortex."],"pmcid":["PMC9889886"],"funding_grant_id":["RF1 MH117815","R01 AG072305","RF1 MH128840","U01 MH114824","U19 NS104648","R01 NS104926","R01AG072305","R01 EY027036","Di6PC00003 D16PC00004 D16PC0005"],"pubmed_authors":["Brittain D","Ih D","Wu J","Takeno MM","Dorkenwald S","Tartavull I","Zung J","Bodor AL","Zlateski A","Buchanan J","Elabbady L","Turner NL","da Costa NM","Bleckert AA","Castro M","Lee K","Torres R","Collman F","Hodge RD","Jordan CS","Popovych S","Seung HS","Glatzer J","Schneider-Mizell C","Jorstad NL","Mu S","Bakken TE","Bumbarger DJ","Seshamani S","Yin W","Silversmith WM","Mahalingam G","Wong W","Reid RC","Bergles DE","Ott C","Lein ES","Macrina T","Wilson AM","Kemnitz N","Lu R","Lippincott-Schwartz J"],"additional_accession":[]},"is_claimable":false,"name":"Oligodendrocyte precursor cells ingest axons in the mouse neocortex.","description":"Neurons in the developing brain undergo extensive structural refinement as nascent circuits adopt their mature form. This physical transformation of neurons is facilitated by the engulfment and degradation of axonal branches and synapses by surrounding glial cells, including microglia and astrocytes. However, the small size of phagocytic organelles and the complex, highly ramified morphology of glia have made it difficult to define the contribution of these and other glial cell types to this crucial process. Here, we used large-scale, serial section transmission electron microscopy (TEM) with computational volume segmentation to reconstruct the complete 3D morphologies of distinct glial types in the mouse visual cortex, providing unprecedented resolution of their morphology and composition","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-26T18:04:09.886Z","creation":"2025-04-06T15:45:10.35Z"},"accession":"S-EPMC9889886","cross_references":{"pubmed":["36417438"],"doi":["10.1073/pnas.2202580119"]}}