biostudies-literatureHellmann JNIDDK NIH HHSNIEHS NIH HHSNational Institutes of Health286-296https://www.ebi.ac.uk/biostudies/studies/S-EPMC9890220biostudies-literatureUnknown29(2)<h4>Background</h4>Inflammatory bowel diseases (IBDs) involve an aberrant host response to intestinal microbiota causing mucosal inflammation and gastrointestinal symptoms. Patient-reported outcomes (PROs) are increasingly important in clinical care and research. Our aim was to examine associations between PROs and fecal microbiota in patients 0 to 22 years of age with IBD.<h4>Methods</h4>A longitudinal, prospective, single-center study tested for associations between microbial community composition via shotgun metagenomics and PROs including stool frequency and rectal bleeding in ulcerative colitis (UC) and abdominal pain and stool frequency in Crohn's disease (CD). Mucosal inflammation was assessed with fecal calprotectin. A negative binomial mixed-effects model including clinical characInflammatory bowel diseasesPatient-Reported Outcomes Correlate With Microbial Community Composition Independent of Mucosal Inflammation in Pediatric Inflammatory Bowel Disease.PMC9890220T32 DK007727T32 ES010957T32 ESO10957-14P30 DK078392R01 HD94862Bezold RHaslam DBLake KDirksing KOllberding NJHellmann JTa ABonkowski EJackson KDenson LAfalsePatient-Reported Outcomes Correlate With Microbial Community Composition Independent of Mucosal Inflammation in Pediatric Inflammatory Bowel Disease.<h4>Background</h4>Inflammatory bowel diseases (IBDs) involve an aberrant host response to intestinal microbiota causing mucosal inflammation and gastrointestinal symptoms. Patient-reported outcomes (PROs) are increasingly important in clinical care and research. Our aim was to examine associations between PROs and fecal microbiota in patients 0 to 22 years of age with IBD.<h4>Methods</h4>A longitudinal, prospective, single-center study tested for associations between microbial community composition via shotgun metagenomics and PROs including stool frequency and rectal bleeding in ulcerative colitis (UC) and abdominal pain and stool frequency in Crohn's disease (CD). Mucosal inflammation was assessed with fecal calprotectin. A negative binomial mixed-effects model including clinical charac2023-01-01T00:00:00Z2023 Feb2025-04-04T20:04:00.472Z2025-04-04T20:04:00.472ZS-EPMC98902203597244010.1093/ibd/izac175