biostudies-literatureZhao TNational Natural Science FoundationBeijing, Guangzhou Institute of Pediatrics/ Guangzhou Women and Children's Medical Center fundsGuangzhou Municipal Science and Technology ProgramBeijing, Guangzhou Institute of Pediatrics/ Guangzhou Women and Children&apos;s Medical Center funds2369-2380https://www.ebi.ac.uk/biostudies/studies/S-EPMC9890293biostudies-literatureUnknown20(12)<h4>Background</h4>GABAergic deficits have been considered to be associated with the pathophysiology of schizophrenia, and hence, GABA receptors subtype A (GABA_ARs) modulators, such as commonly used volatile anesthetic sevoflurane, may have therapeutic values for schizophrenia. The present study investigates the therapeutic effectiveness of low-concentration sevoflurane in MK801-induced schizophrenia-like mice and schizophrenia patients.<h4>Methods</h4>Three weeks after MK801 administration (0.5 mg kg^-1, i.p. twice a day for 5 days), mice were exposed to 1% sevoflurane 1hr/day for 5 days. Behavioral tests, immunohistochemical analysis, western blot assay, and electrophysiology assessments were performed 1-week post-exposure. Ten schizophrenia patients received 1% sevoCurrent neuropharmacologySevoflurane Ameliorates Schizophrenia in a Mouse Model and Patients: A Pre-Clinical and Clinical Feasibility Study.PMC989029381870823GCP-2019-00281671116GCP-2018-001GCP-2018-001, GCP-2019-00281671116, 81870823201803010025Wu LZhou QLin CQin JZhao TShi ZWang YMa DSong XLing NfalseSevoflurane Ameliorates Schizophrenia in a Mouse Model and Patients: A Pre-Clinical and Clinical Feasibility Study.<h4>Background</h4>GABAergic deficits have been considered to be associated with the pathophysiology of schizophrenia, and hence, GABA receptors subtype A (GABA_ARs) modulators, such as commonly used volatile anesthetic sevoflurane, may have therapeutic values for schizophrenia. The present study investigates the therapeutic effectiveness of low-concentration sevoflurane in MK801-induced schizophrenia-like mice and schizophrenia patients.<h4>Methods</h4>Three weeks after MK801 administration (0.5 mg kg^-1, i.p. twice a day for 5 days), mice were exposed to 1% sevoflurane 1hr/day for 5 days. Behavioral tests, immunohistochemical analysis, western blot assay, and electrophysiology assessments were performed 1-week post-exposure. Ten schizophrenia patients received 1% sevo2022-01-01T00:00:00Z2022 Nov2025-04-26T13:33:50.307Z2025-04-06T14:14:53.141ZS-EPMC98902933527259310.2174/1570159X20666220310115846