{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["21(1)"],"submitter":["Shen H"],"funding":["Hospital Fund of Lanzhou University First Affiliated Hospital","Science and Technology Program of Gansu Province","the National Natural Science Foundation of China"],"pubmed_abstract":["Owing to its difficulty in degrading and ease of accumulation in the body, perfluorooctanoic acid (PFOA) has a detrimental effect on reproduction. This study aimed to examine the effect of PFOA concentration in follicular fluid during ovulation stimulation on embryo quality and the impact of PFOA exposure on the metabolic components of follicular fluid. This was a single-center prospective study that included 25 patients with diminished ovarian reserve (DOR), 25 with normal ovarian reserve (NOR), and 25 with polycystic ovary syndrome (PCOS). Follicular fluid samples were analyzed using ultra-high performance liquid chromatography-tandem mass spectrometry. We demonstrated that the PFOA levels of follicular fluid in the DOR group were higher than those in the NOR group and PCOS group (P < 0."],"journal":["Reproductive biology and endocrinology : RB&E"],"pagination":["16"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9890749"],"repository":["biostudies-literature"],"pubmed_title":["Effect of PFOA exposure on diminished ovarian reserve and its metabolism."],"pmcid":["PMC9890749"],"pubmed_authors":["Wu J","Liu L","Li Q","Han S","Shen H","Jiang Y","Gao M","Jia T","Zhang X","Sun H","Wang Y","Yu X","Xin Y"],"additional_accession":[]},"is_claimable":false,"name":"Effect of PFOA exposure on diminished ovarian reserve and its metabolism.","description":"Owing to its difficulty in degrading and ease of accumulation in the body, perfluorooctanoic acid (PFOA) has a detrimental effect on reproduction. This study aimed to examine the effect of PFOA concentration in follicular fluid during ovulation stimulation on embryo quality and the impact of PFOA exposure on the metabolic components of follicular fluid. This was a single-center prospective study that included 25 patients with diminished ovarian reserve (DOR), 25 with normal ovarian reserve (NOR), and 25 with polycystic ovary syndrome (PCOS). Follicular fluid samples were analyzed using ultra-high performance liquid chromatography-tandem mass spectrometry. We demonstrated that the PFOA levels of follicular fluid in the DOR group were higher than those in the NOR group and PCOS group (P < 0.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2026-07-10T03:21:25.217Z","creation":"2025-04-06T15:43:45.62Z"},"accession":"S-EPMC9890749","cross_references":{"pubmed":["36726108"],"doi":["10.1186/s12958-023-01056-y"]}}