{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pan J"],"funding":["Suzhou municipal key clinical disciplines cultivate program","Suzhou Medical Innovation Applied Research Project","National Natural Science Foundation of China","Innovative and Entrepreneurial Talent Program of Jiangsu for Guohua Shi team, the China Postdoctoral Science Foundation","Projects of International Cooperation of Jiangsu Province"],"pagination":["10"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9890863"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(1)"],"pubmed_abstract":["<h4>Background</h4>Glioblastoma (GBM) is the most common malignant intracranial tumor with a low survival rate. However, only few drugs responsible for GBM therpies, hence new drug development for it is highly required. The natural product Cudraflavone B (CUB) has been reported to potentially kill a variety of tumor cells. Currently, its anit-cancer effect on GBM still remains unknown. Herein, we investigated whether CUB could affect the proliferation and apoptosis of GBM cells to show anti-GBM potential.<h4>Results</h4>CUB selectively inhibited cell viability and induced cell apoptosis by activating the endoplasmic reticulum stress (ER stress) related pathway, as well as harnessing the autophagy-related PI3K/mTOR/LC3B signaling pathway. Typical morphological changes of autophagy were also"],"journal":["BMC neuroscience"],"pubmed_title":["Cudraflavone B induces human glioblastoma cells apoptosis via ER stress-induced autophagy."],"pmcid":["PMC9890863"],"funding_grant_id":["81903028","SZFCXK202142","BZ2020004","SKYD2022090","2020M671599"],"pubmed_authors":["Sun M","Liu Y","Pan J","Yang J","Zhao R","Zhou Y","Zhang R","Ahmad N","Dong C"],"additional_accession":[]},"is_claimable":false,"name":"Cudraflavone B induces human glioblastoma cells apoptosis via ER stress-induced autophagy.","description":"<h4>Background</h4>Glioblastoma (GBM) is the most common malignant intracranial tumor with a low survival rate. However, only few drugs responsible for GBM therpies, hence new drug development for it is highly required. The natural product Cudraflavone B (CUB) has been reported to potentially kill a variety of tumor cells. Currently, its anit-cancer effect on GBM still remains unknown. Herein, we investigated whether CUB could affect the proliferation and apoptosis of GBM cells to show anti-GBM potential.<h4>Results</h4>CUB selectively inhibited cell viability and induced cell apoptosis by activating the endoplasmic reticulum stress (ER stress) related pathway, as well as harnessing the autophagy-related PI3K/mTOR/LC3B signaling pathway. Typical morphological changes of autophagy were also","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-21T22:50:33.239Z","creation":"2025-04-05T18:52:59.039Z"},"accession":"S-EPMC9890863","cross_references":{"pubmed":["36721107"],"doi":["10.1186/s12868-023-00778-4"]}}