biostudies-literaturePan JSuzhou municipal key clinical disciplines cultivate programSuzhou Medical Innovation Applied Research ProjectNational Natural Science Foundation of ChinaInnovative and Entrepreneurial Talent Program of Jiangsu for Guohua Shi team, the China Postdoctoral Science FoundationProjects of International Cooperation of Jiangsu Province10https://www.ebi.ac.uk/biostudies/studies/S-EPMC9890863biostudies-literatureUnknown24(1)<h4>Background</h4>Glioblastoma (GBM) is the most common malignant intracranial tumor with a low survival rate. However, only few drugs responsible for GBM therpies, hence new drug development for it is highly required. The natural product Cudraflavone B (CUB) has been reported to potentially kill a variety of tumor cells. Currently, its anit-cancer effect on GBM still remains unknown. Herein, we investigated whether CUB could affect the proliferation and apoptosis of GBM cells to show anti-GBM potential.<h4>Results</h4>CUB selectively inhibited cell viability and induced cell apoptosis by activating the endoplasmic reticulum stress (ER stress) related pathway, as well as harnessing the autophagy-related PI3K/mTOR/LC3B signaling pathway. Typical morphological changes of autophagy were alsoBMC neuroscienceCudraflavone B induces human glioblastoma cells apoptosis via ER stress-induced autophagy.PMC989086381903028SZFCXK202142BZ2020004SKYD20220902020M671599Sun MLiu YPan JYang JZhao RZhou YZhang RAhmad NDong CfalseCudraflavone B induces human glioblastoma cells apoptosis via ER stress-induced autophagy.<h4>Background</h4>Glioblastoma (GBM) is the most common malignant intracranial tumor with a low survival rate. However, only few drugs responsible for GBM therpies, hence new drug development for it is highly required. The natural product Cudraflavone B (CUB) has been reported to potentially kill a variety of tumor cells. Currently, its anit-cancer effect on GBM still remains unknown. Herein, we investigated whether CUB could affect the proliferation and apoptosis of GBM cells to show anti-GBM potential.<h4>Results</h4>CUB selectively inhibited cell viability and induced cell apoptosis by activating the endoplasmic reticulum stress (ER stress) related pathway, as well as harnessing the autophagy-related PI3K/mTOR/LC3B signaling pathway. Typical morphological changes of autophagy were also2023-01-01T00:00:00Z2023 Jan2025-04-21T22:50:33.239Z2025-04-05T18:52:59.039ZS-EPMC98908633672110710.1186/s12868-023-00778-4