{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["23(1)"],"submitter":["Cheng XF"],"pubmed_abstract":["<h4>Background/aims</h4>The activation of the complement system and subsequent inflammatory responses are important features of myocardial ischemia/reperfusion (I/R) injury. Exosomes are nanoscale extracellular vesicles that play a significant role in remote ischemic preconditioning (RIPC) cardioprotection. The present study aimed to test whether RIPC-induced plasma exosomes (RIPC-Exo) exert protective effects on myocardial I/R injury by inhibiting complement activation and inflammation and whether exosomal heat shock protein 90 (HSP90) mediates these effects.<h4>Methods</h4>Rat hearts underwent 30 min of coronary ligation followed by 2 h of reperfusion. Plasma exosomes were isolated from RIPC rats and injected into the infarcted myocardium immediately after ligation. Sixty rats were rando"],"journal":["BMC cardiovascular disorders"],"pagination":["58"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9890892"],"repository":["biostudies-literature"],"pubmed_title":["Exosomal HSP90 induced by remote ischemic preconditioning alleviates myocardial ischemia/reperfusion injury by inhibiting complement activation and inflammation."],"pmcid":["PMC9890892"],"pubmed_authors":["Wang M","Tu RH","He ST","Bi Q","Cheng XF","Zhong GQ","Meng JJ"],"additional_accession":[]},"is_claimable":false,"name":"Exosomal HSP90 induced by remote ischemic preconditioning alleviates myocardial ischemia/reperfusion injury by inhibiting complement activation and inflammation.","description":"<h4>Background/aims</h4>The activation of the complement system and subsequent inflammatory responses are important features of myocardial ischemia/reperfusion (I/R) injury. Exosomes are nanoscale extracellular vesicles that play a significant role in remote ischemic preconditioning (RIPC) cardioprotection. The present study aimed to test whether RIPC-induced plasma exosomes (RIPC-Exo) exert protective effects on myocardial I/R injury by inhibiting complement activation and inflammation and whether exosomal heat shock protein 90 (HSP90) mediates these effects.<h4>Methods</h4>Rat hearts underwent 30 min of coronary ligation followed by 2 h of reperfusion. Plasma exosomes were isolated from RIPC rats and injected into the infarcted myocardium immediately after ligation. Sixty rats were rando","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2026-07-16T21:13:21.321Z","creation":"2025-04-05T20:52:34.972Z"},"accession":"S-EPMC9890892","cross_references":{"pubmed":["36726083"],"doi":["10.1186/s12872-023-03043-y"]}}