biostudies-literatureChen GCNIDDK NIH HHSNational Institute of Diabetes and Digestive and Kidney DiseasesNIEHS NIH HHSNHLBI NIH HHSNational Heart, Lung, and Blood InstituteNHGRI NIH HHS1133-1144https://www.ebi.ac.uk/biostudies/studies/S-EPMC9890970biostudies-literatureUnknown65(7)<h4>Aims/hypothesis</h4>We aimed to evaluate associations of multiple recommended dietary patterns (i.e. the alternate Mediterranean diet [aMED], the Healthy Eating Index [HEI]-2015 and the healthful Plant-based Diet Index [hPDI]) with serum metabolite profile, and to examine dietary-pattern-associated metabolites in relation to incident diabetes.<h4>Methods</h4>We included 2842 adult participants free from diabetes, CVD and cancer during baseline recruitment of the Hispanic Community Health Study/Study of Latinos. Metabolomics profiling of fasting serum was performed using an untargeted approach. Dietary pattern scores were derived using information collected by two 24 h dietary recalls. Dietary-pattern-associated metabolites were identified using multivariable survey linear regressions aDiabetologiaHealthful eating patterns, serum metabolite profile and risk of diabetes in a population-based prospective study of US Hispanics/Latinos.PMC9890970K01 HL129892R01HL060712HHSN268201300005CP30 DK111022P30 ES030285HHSN268201300001CHHSN268201300004CR01 DK126698R01 DK120870HHSN268201300003CP30 DK046200R01 HL060712R01 HL136266R01 HL140976R01DK119268R01 DK112940N01HC65236N01HC65237N01HC65234N01HC65235UM1 HG008898R01 DK119268N01HC65233Daviglus MLLi JHu FBMossavar-Rahman YBoerwinkle EPerkins DLChai JCSotres-Alvarez DQi QXing JYu BChen GCShan ZMoon JYMattei JBurk RDKaplan RCfalseHealthful eating patterns, serum metabolite profile and risk of diabetes in a population-based prospective study of US Hispanics/Latinos.<h4>Aims/hypothesis</h4>We aimed to evaluate associations of multiple recommended dietary patterns (i.e. the alternate Mediterranean diet [aMED], the Healthy Eating Index [HEI]-2015 and the healthful Plant-based Diet Index [hPDI]) with serum metabolite profile, and to examine dietary-pattern-associated metabolites in relation to incident diabetes.<h4>Methods</h4>We included 2842 adult participants free from diabetes, CVD and cancer during baseline recruitment of the Hispanic Community Health Study/Study of Latinos. Metabolomics profiling of fasting serum was performed using an untargeted approach. Dietary pattern scores were derived using information collected by two 24 h dietary recalls. Dietary-pattern-associated metabolites were identified using multivariable survey linear regressions a2022-01-01T00:00:00Z2022 Jul2025-04-21T15:10:20.963Z2025-04-21T15:10:20.963ZS-EPMC98909703535756110.1007/s00125-022-05690-w