{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Strohmeier V"],"funding":["Bundesministerium für Bildung und Forschung","Deutsche Forschungsgemeinschaft","Universitätsklinikum Freiburg","Agentura Pro Zdravotnický Výzkum České Republiky","Fundação de Amparo à Pesquisa do Estado de São Paulo"],"pagination":["371-390"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9892141"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["43(2)"],"pubmed_abstract":["<h4>Purpose</h4>About 15% of patients with common variable immunodeficiency (CVID) develop a small intestinal enteropathy, which resembles celiac disease with regard to histopathology but evolves from a distinct, poorly defined pathogenesis that has been linked in some cases to chronic norovirus (NV) infection. Interferon-driven inflammation is a prominent feature of CVID enteropathy, but it remains unknown how NV infection may contribute.<h4>Methods</h4>Duodenal biopsies of CVID patients, stratified according to the presence of villous atrophy (VA), IgA plasma cells (PCs), and chronic NV infection, were investigated by flow cytometry, multi-epitope-ligand cartography, bulk RNA-sequencing, and RT-qPCR of genes of interest.<h4>Results</h4>VA development was connected to the lack of intestin"],"journal":["Journal of clinical immunology"],"pubmed_title":["Interferon-Driven Immune Dysregulation in Common Variable Immunodeficiency-Associated Villous Atrophy and Norovirus Infection."],"pmcid":["PMC9892141"],"funding_grant_id":["CIBSS–EXC-2189–Project ID 390939984","GAIN 748 01GM1910A","RESIST–EXC 2155–Project ID 517 390874280","SFB 1160 IMPATH project Z02N","NV18-05–00162","FAPESP grant 2020/01688-0","CRC1453 (Project ID 431984000 - S1)","SFB 1160 IMPATH project A04","SFB 1160 IMPATH project B05","CRC1479 (Project ID: 441891347- S1)","project Z01","Z1","CRC 850 subprojects C9","FKZ 01ZZ1801B","NU20-05–00282","GR1617/14-1/iPAD","SFB 1160 IMPATH project Z01","TRR167"],"pubmed_authors":["Grimbacher B","Friedmann D","Bulashevska A","Eckert M","Gutenberger S","Schell C","Boerries M","Klocperk A","Seidl M","Grawe K","Shabani M","Pascual-Reguant A","Proietti M","Strohmeier V","Harder I","Hauser AE","Unger S","von Spee-Mayer C","Goldacker S","Warnatz K","Marques OC","Keller B","Provaznik J","Hasselblatt P","Andrieux G","Benes V"],"additional_accession":[]},"is_claimable":false,"name":"Interferon-Driven Immune Dysregulation in Common Variable Immunodeficiency-Associated Villous Atrophy and Norovirus Infection.","description":"<h4>Purpose</h4>About 15% of patients with common variable immunodeficiency (CVID) develop a small intestinal enteropathy, which resembles celiac disease with regard to histopathology but evolves from a distinct, poorly defined pathogenesis that has been linked in some cases to chronic norovirus (NV) infection. Interferon-driven inflammation is a prominent feature of CVID enteropathy, but it remains unknown how NV infection may contribute.<h4>Methods</h4>Duodenal biopsies of CVID patients, stratified according to the presence of villous atrophy (VA), IgA plasma cells (PCs), and chronic NV infection, were investigated by flow cytometry, multi-epitope-ligand cartography, bulk RNA-sequencing, and RT-qPCR of genes of interest.<h4>Results</h4>VA development was connected to the lack of intestin","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2026-07-16T20:12:18.623Z","creation":"2025-04-05T23:23:18.959Z"},"accession":"S-EPMC9892141","cross_references":{"pubmed":["36282455"],"doi":["10.1007/s10875-022-01379-2"]}}