biostudies-literatureStrohmeier VBundesministerium für Bildung und ForschungDeutsche ForschungsgemeinschaftUniversitätsklinikum FreiburgAgentura Pro Zdravotnický Výzkum České RepublikyFundação de Amparo à Pesquisa do Estado de São Paulo371-390https://www.ebi.ac.uk/biostudies/studies/S-EPMC9892141biostudies-literatureUnknown43(2)<h4>Purpose</h4>About 15% of patients with common variable immunodeficiency (CVID) develop a small intestinal enteropathy, which resembles celiac disease with regard to histopathology but evolves from a distinct, poorly defined pathogenesis that has been linked in some cases to chronic norovirus (NV) infection. Interferon-driven inflammation is a prominent feature of CVID enteropathy, but it remains unknown how NV infection may contribute.<h4>Methods</h4>Duodenal biopsies of CVID patients, stratified according to the presence of villous atrophy (VA), IgA plasma cells (PCs), and chronic NV infection, were investigated by flow cytometry, multi-epitope-ligand cartography, bulk RNA-sequencing, and RT-qPCR of genes of interest.<h4>Results</h4>VA development was connected to the lack of intestinJournal of clinical immunologyInterferon-Driven Immune Dysregulation in Common Variable Immunodeficiency-Associated Villous Atrophy and Norovirus Infection.PMC9892141CIBSS–EXC-2189–Project ID 390939984GAIN 748 01GM1910ARESIST–EXC 2155–Project ID 517 390874280SFB 1160 IMPATH project Z02NNV18-05–00162FAPESP grant 2020/01688-0CRC1453 (Project ID 431984000 - S1)SFB 1160 IMPATH project A04SFB 1160 IMPATH project B05CRC1479 (Project ID: 441891347- S1)project Z01Z1CRC 850 subprojects C9FKZ 01ZZ1801BNU20-05–00282GR1617/14-1/iPADSFB 1160 IMPATH project Z01TRR167Grimbacher BFriedmann DBulashevska AEckert MGutenberger SSchell CBoerries MKlocperk ASeidl MGrawe KShabani MPascual-Reguant AProietti MStrohmeier VHarder IHauser AEUnger Svon Spee-Mayer CGoldacker SWarnatz KMarques OCKeller BProvaznik JHasselblatt PAndrieux GBenes VfalseInterferon-Driven Immune Dysregulation in Common Variable Immunodeficiency-Associated Villous Atrophy and Norovirus Infection.<h4>Purpose</h4>About 15% of patients with common variable immunodeficiency (CVID) develop a small intestinal enteropathy, which resembles celiac disease with regard to histopathology but evolves from a distinct, poorly defined pathogenesis that has been linked in some cases to chronic norovirus (NV) infection. Interferon-driven inflammation is a prominent feature of CVID enteropathy, but it remains unknown how NV infection may contribute.<h4>Methods</h4>Duodenal biopsies of CVID patients, stratified according to the presence of villous atrophy (VA), IgA plasma cells (PCs), and chronic NV infection, were investigated by flow cytometry, multi-epitope-ligand cartography, bulk RNA-sequencing, and RT-qPCR of genes of interest.<h4>Results</h4>VA development was connected to the lack of intestin2023-01-01T00:00:00Z2023 Feb2026-07-16T20:12:18.623Z2025-04-05T23:23:18.959ZS-EPMC98921413628245510.1007/s10875-022-01379-2