{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sen R"],"funding":["BLRD VA","NIAMS NIH HHS"],"pagination":["232-241"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9892177"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["75(2)"],"pubmed_abstract":["<h4>Objectives</h4>This study was conducted to assess the utility of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in predicting radiographic sacroiliitis and active disease in axial spondyloarthritis (SpA) and to explore the association between use of a tumor necrosis factor inhibitor (TNFi) and these laboratory values compared with traditional inflammatory markers.<h4>Methods</h4>Observational data from the Program to Understand the Longterm Outcomes in Spondyloarthritis (PULSAR) registry were analyzed. We generated receiver operating characteristic curves to calculate laboratory cutoff values; we used these values in multivariable logistic regression models to identify associations with radiographically confirmed sacroiliitis and active disease. We also use"],"journal":["Arthritis & rheumatology (Hoboken, N.J.)"],"pubmed_title":["Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio as Biomarkers in Axial Spondyloarthritis: Observational Studies From the Program to Understand the Longterm Outcomes in Spondyloarthritis Registry."],"pmcid":["PMC9892177"],"funding_grant_id":["IK2 BX004523","T32 AR007534"],"pubmed_authors":["Cheng E","Kim E","Hashim M","Napier RJ","Fernandez A","Reimold A","Sen R","Maier KD","Raychadhuri SP","Walsh JA","Kerr GS","Fang MA","Chang E","Caplan L","Anderson ER","Hou JK","Manning ES"],"additional_accession":[]},"is_claimable":false,"name":"Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio as Biomarkers in Axial Spondyloarthritis: Observational Studies From the Program to Understand the Longterm Outcomes in Spondyloarthritis Registry.","description":"<h4>Objectives</h4>This study was conducted to assess the utility of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in predicting radiographic sacroiliitis and active disease in axial spondyloarthritis (SpA) and to explore the association between use of a tumor necrosis factor inhibitor (TNFi) and these laboratory values compared with traditional inflammatory markers.<h4>Methods</h4>Observational data from the Program to Understand the Longterm Outcomes in Spondyloarthritis (PULSAR) registry were analyzed. We generated receiver operating characteristic curves to calculate laboratory cutoff values; we used these values in multivariable logistic regression models to identify associations with radiographically confirmed sacroiliitis and active disease. We also use","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2026-03-18T14:10:42.241Z","creation":"2025-05-29T21:30:56.765Z"},"accession":"S-EPMC9892177","cross_references":{"pubmed":["36053919"],"doi":["10.1002/art.42333"]}}