biostudies-literatureSen RBLRD VANIAMS NIH HHS232-241https://www.ebi.ac.uk/biostudies/studies/S-EPMC9892177biostudies-literatureUnknown75(2)<h4>Objectives</h4>This study was conducted to assess the utility of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in predicting radiographic sacroiliitis and active disease in axial spondyloarthritis (SpA) and to explore the association between use of a tumor necrosis factor inhibitor (TNFi) and these laboratory values compared with traditional inflammatory markers.<h4>Methods</h4>Observational data from the Program to Understand the Longterm Outcomes in Spondyloarthritis (PULSAR) registry were analyzed. We generated receiver operating characteristic curves to calculate laboratory cutoff values; we used these values in multivariable logistic regression models to identify associations with radiographically confirmed sacroiliitis and active disease. We also useArthritis & rheumatology (Hoboken, N.J.)Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio as Biomarkers in Axial Spondyloarthritis: Observational Studies From the Program to Understand the Longterm Outcomes in Spondyloarthritis Registry.PMC9892177IK2 BX004523T32 AR007534Cheng EKim EHashim MNapier RJFernandez AReimold ASen RMaier KDRaychadhuri SPWalsh JAKerr GSFang MAChang ECaplan LAnderson ERHou JKManning ESfalseNeutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio as Biomarkers in Axial Spondyloarthritis: Observational Studies From the Program to Understand the Longterm Outcomes in Spondyloarthritis Registry.<h4>Objectives</h4>This study was conducted to assess the utility of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in predicting radiographic sacroiliitis and active disease in axial spondyloarthritis (SpA) and to explore the association between use of a tumor necrosis factor inhibitor (TNFi) and these laboratory values compared with traditional inflammatory markers.<h4>Methods</h4>Observational data from the Program to Understand the Longterm Outcomes in Spondyloarthritis (PULSAR) registry were analyzed. We generated receiver operating characteristic curves to calculate laboratory cutoff values; we used these values in multivariable logistic regression models to identify associations with radiographically confirmed sacroiliitis and active disease. We also use2023-01-01T00:00:00Z2023 Feb2026-03-18T14:10:42.241Z2025-05-29T21:30:56.765ZS-EPMC98921773605391910.1002/art.42333