{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Wang Y"],"pubmed_abstract":["<b>Background and Aims:</b> Methionine has been proven to inhibit addictive behaviors of cocaine dependence. This study aimed to identify the potential mechanisms of MET relating to its inhibitory effects on cocaine induced cellular and behavioral changes. <b>Methods:</b> MRNA and miRNA high-throughput sequencing of the prefrontal cortex in a mouse model of cocaine conditioned place preference (CPP) combined with L-methionine was performed. Differentially expressed miRNAs (DE-miRNAs) and differentially expressed genes (DEGs) regulated by cocaine and inhibited by L-methionine were identified. DEGs were mapped to STRING database to construct a protein-protein interaction (PPI) network. Then, the identified DEGs were subjected to the DAVID webserver for functional annotation. Finally, miRNA-m"],"journal":["Frontiers in genetics"],"pagination":["1076156"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9893020"],"repository":["biostudies-literature"],"pubmed_title":["Identification of miRNA-mediated gene regulatory networks in L-methionine exposure counteracts cocaine-conditioned place preference in mice."],"pmcid":["PMC9893020"],"pubmed_authors":["Zhao M","Yang L","Zhang K","Wang Y","Zhou H"],"additional_accession":[]},"is_claimable":false,"name":"Identification of miRNA-mediated gene regulatory networks in L-methionine exposure counteracts cocaine-conditioned place preference in mice.","description":"<b>Background and Aims:</b> Methionine has been proven to inhibit addictive behaviors of cocaine dependence. This study aimed to identify the potential mechanisms of MET relating to its inhibitory effects on cocaine induced cellular and behavioral changes. <b>Methods:</b> MRNA and miRNA high-throughput sequencing of the prefrontal cortex in a mouse model of cocaine conditioned place preference (CPP) combined with L-methionine was performed. Differentially expressed miRNAs (DE-miRNAs) and differentially expressed genes (DEGs) regulated by cocaine and inhibited by L-methionine were identified. DEGs were mapped to STRING database to construct a protein-protein interaction (PPI) network. Then, the identified DEGs were subjected to the DAVID webserver for functional annotation. Finally, miRNA-m","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-05-28T12:55:32.696Z","creation":"2025-02-18T22:34:44.508Z"},"accession":"S-EPMC9893020","cross_references":{"pubmed":["36744178"],"doi":["10.3389/fgene.2022.1076156"]}}