biostudies-literatureCanali MMAgence Nationale de la RechercheCanceropole Provence Alpes Côte d’AzurLABEX SIGNALIFE15https://www.ebi.ac.uk/biostudies/studies/S-EPMC9893572biostudies-literatureUnknown23(1)While positive social-behavioral factors predict longer survival in cancer patients, the underlying mechanisms are unknown. Since tumor metastasis are the major cancer mortality factor, we investigated how an enriched environment (EE) conductive to enhanced sensory, cognitive and motor stimulation impact metastatic progression in lungs following intravasation in the circulation. We find that mice housed in EE exhibited reduced number of lung metastatic foci compared to control mice housed in a standard environment (SE). Compared to SE mice, EE mice increased lung inflammation as early as 4 days after circulating tumor cells extravasation. The impact of environmental signals on lung metastasis is independent of adrenergic receptors signaling. By contrast, we find that serum corticosterone lCancer cell internationalEnvironmental signals perceived by the brain abate pro-metastatic monocytes by dampening glucocorticoids receptor signaling.PMC9893572AsthmaTreatANR-11-LABX-0028-01Chabry JCanali MMGuyot MMougneau EGlaichenhaus NPrevost-Blondel ASchmid-Alliana ASimon THypolite NNicolas SKarimdjee Soilihi BHofman PPanzolini CDaoudlarian DPetit-Paitel AKato MSchmid-Antomarchi HBourdely PSoria JBlancou PfalseEnvironmental signals perceived by the brain abate pro-metastatic monocytes by dampening glucocorticoids receptor signaling.While positive social-behavioral factors predict longer survival in cancer patients, the underlying mechanisms are unknown. Since tumor metastasis are the major cancer mortality factor, we investigated how an enriched environment (EE) conductive to enhanced sensory, cognitive and motor stimulation impact metastatic progression in lungs following intravasation in the circulation. We find that mice housed in EE exhibited reduced number of lung metastatic foci compared to control mice housed in a standard environment (SE). Compared to SE mice, EE mice increased lung inflammation as early as 4 days after circulating tumor cells extravasation. The impact of environmental signals on lung metastasis is independent of adrenergic receptors signaling. By contrast, we find that serum corticosterone l2023-01-01T00:00:00Z2023 Feb2026-07-16T20:11:46.814Z2025-05-29T19:45:32.042ZS-EPMC98935723672617310.1186/s12935-023-02855-4