{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11"],"submitter":["Huang P"],"pubmed_abstract":["Hepatitis C remains a major public health problem in the world. The host immune system plays a key role in viral clearance. This study aimed to investigate the connection between retinoic acid-inducible gene I-like (RIG-I-like) receptor gene polymorphism and hepatitis C chronicity in the Chinese Han population. The current study genotyped three SNPs (IFIH1 rs10930046 and DHX58 rs2074158, rs2074160) to assess their association with the chronicity of hepatitis C virus (HCV) infection among 1,590 participants (590 spontaneous HCV clearance cases and 1,000 persistent infection patients). Our research shows that DHX58 rs2074158-G allele (dominant model: adjusted OR = 1.53, 95% CI [1.20-1.95], <i>P</i> = 0.001; additive model: adjusted OR = 1.50, 95% CI [1.27-1.78], <i>P</i> < 0.001) and IFIH1 r"],"journal":["PeerJ"],"pagination":["e14740"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9893905"],"repository":["biostudies-literature"],"pubmed_title":["Genetic variants of IFIH1 and DHX58 affect the chronicity of hepatitis C in the Chinese Han population."],"pmcid":["PMC9893905"],"pubmed_authors":["Zhu P","Zhang JW","Hou YQ","Zhang Y","Yin R","Yue M","Wu JJ","Huang P","Yu RB","Hou W"],"additional_accession":[]},"is_claimable":false,"name":"Genetic variants of IFIH1 and DHX58 affect the chronicity of hepatitis C in the Chinese Han population.","description":"Hepatitis C remains a major public health problem in the world. The host immune system plays a key role in viral clearance. This study aimed to investigate the connection between retinoic acid-inducible gene I-like (RIG-I-like) receptor gene polymorphism and hepatitis C chronicity in the Chinese Han population. The current study genotyped three SNPs (IFIH1 rs10930046 and DHX58 rs2074158, rs2074160) to assess their association with the chronicity of hepatitis C virus (HCV) infection among 1,590 participants (590 spontaneous HCV clearance cases and 1,000 persistent infection patients). Our research shows that DHX58 rs2074158-G allele (dominant model: adjusted OR = 1.53, 95% CI [1.20-1.95], <i>P</i> = 0.001; additive model: adjusted OR = 1.50, 95% CI [1.27-1.78], <i>P</i> < 0.001) and IFIH1 r","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2026-05-28T19:00:36.385Z","creation":"2025-02-19T00:13:59.182Z"},"accession":"S-EPMC9893905","cross_references":{"pubmed":["36743960"],"doi":["10.7717/peerj.14740"]}}