biostudies-literatureUnknown11Huang PHepatitis C remains a major public health problem in the world. The host immune system plays a key role in viral clearance. This study aimed to investigate the connection between retinoic acid-inducible gene I-like (RIG-I-like) receptor gene polymorphism and hepatitis C chronicity in the Chinese Han population. The current study genotyped three SNPs (IFIH1 rs10930046 and DHX58 rs2074158, rs2074160) to assess their association with the chronicity of hepatitis C virus (HCV) infection among 1,590 participants (590 spontaneous HCV clearance cases and 1,000 persistent infection patients). Our research shows that DHX58 rs2074158-G allele (dominant model: adjusted OR = 1.53, 95% CI [1.20-1.95], <i>P</i> = 0.001; additive model: adjusted OR = 1.50, 95% CI [1.27-1.78], <i>P</i> < 0.001) and IFIH1 rPeerJe14740https://www.ebi.ac.uk/biostudies/studies/S-EPMC9893905biostudies-literatureGenetic variants of IFIH1 and DHX58 affect the chronicity of hepatitis C in the Chinese Han population.PMC9893905Zhu PZhang JWHou YQZhang YYin RYue MWu JJHuang PYu RBHou WfalseGenetic variants of IFIH1 and DHX58 affect the chronicity of hepatitis C in the Chinese Han population.Hepatitis C remains a major public health problem in the world. The host immune system plays a key role in viral clearance. This study aimed to investigate the connection between retinoic acid-inducible gene I-like (RIG-I-like) receptor gene polymorphism and hepatitis C chronicity in the Chinese Han population. The current study genotyped three SNPs (IFIH1 rs10930046 and DHX58 rs2074158, rs2074160) to assess their association with the chronicity of hepatitis C virus (HCV) infection among 1,590 participants (590 spontaneous HCV clearance cases and 1,000 persistent infection patients). Our research shows that DHX58 rs2074158-G allele (dominant model: adjusted OR = 1.53, 95% CI [1.20-1.95], <i>P</i> = 0.001; additive model: adjusted OR = 1.50, 95% CI [1.27-1.78], <i>P</i> < 0.001) and IFIH1 r2023-01-01T00:00:00Z20232026-05-28T19:00:36.385Z2025-02-19T00:13:59.182ZS-EPMC98939053674396010.7717/peerj.14740