{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tang W"],"funding":["United States Department of Defense | United States Navy | Office of Naval Research","Vetenskapsrådet","U.S. Department of Energy (DOE)","Vetenskapsrådet (Swedish Research Council)","United States Department of Defense | United States Navy | Office of Naval Research (ONR)","National Natural Science Foundation of China","Knut och Alice Wallenbergs Stiftelse","National Science Foundation (NSF)","Engineering and Physical Sciences Research Council","U.S. Department of Energy","Welch Foundation","Knut och Alice Wallenbergs Stiftelse (Knut and Alice Wallenberg Foundation)","National Science Foundation","National Natural Science Foundation of China (National Science Foundation of China)"],"pagination":["561"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9893984"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["Modifiers are commonly used in natural, biological, and synthetic crystallization to tailor the growth of diverse materials. Here, we identify tautomers as a new class of modifiers where the dynamic interconversion between solute and its corresponding tautomer(s) produces native crystal growth inhibitors. The macroscopic and microscopic effects imposed by inhibitor-crystal interactions reveal dual mechanisms of inhibition where tautomer occlusion within crystals that leads to natural bending, tunes elastic modulus, and selectively alters the rate of crystal dissolution. Our study focuses on ammonium urate crystallization and shows that the keto-enol form of urate, which exists as a minor tautomer, is a potent inhibitor that nearly suppresses crystal growth at select solution alkalinity and"],"journal":["Nature communications"],"pubmed_title":["Tautomerism unveils a self-inhibition mechanism of crystallization."],"pmcid":["PMC9893984"],"funding_grant_id":["DE-AC02-05CH11231","N00014-21-1-2173","1652694","E-1794","2012.0112","VR 2019-00815","2018.0237","EP/R032858/1","N00014-20-1-2083","VR 2017-04321","NNSFC 22278300","EP/P006965/1"],"pubmed_authors":["Kang X","Geng X","Rimer JD","Chauhan VP","Mpourmpakis G","Mo H","Morales-Rivera CA","Zou X","Srirambhatla VK","Kisielowski C","Tu Q","Florence AJ","Calderon HA","Tang W","Yang T","Hernandez FCR","Hong S"],"additional_accession":[]},"is_claimable":false,"name":"Tautomerism unveils a self-inhibition mechanism of crystallization.","description":"Modifiers are commonly used in natural, biological, and synthetic crystallization to tailor the growth of diverse materials. Here, we identify tautomers as a new class of modifiers where the dynamic interconversion between solute and its corresponding tautomer(s) produces native crystal growth inhibitors. The macroscopic and microscopic effects imposed by inhibitor-crystal interactions reveal dual mechanisms of inhibition where tautomer occlusion within crystals that leads to natural bending, tunes elastic modulus, and selectively alters the rate of crystal dissolution. Our study focuses on ammonium urate crystallization and shows that the keto-enol form of urate, which exists as a minor tautomer, is a potent inhibitor that nearly suppresses crystal growth at select solution alkalinity and","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2026-07-16T21:13:44.059Z","creation":"2025-04-04T18:43:58.891Z"},"accession":"S-EPMC9893984","cross_references":{"pubmed":["36732334"],"doi":["10.1038/s41467-023-35924-3"]}}