biostudies-literatureGill RMNCATS NIH HHSNIDDK NIH HHSe0033https://www.ebi.ac.uk/biostudies/studies/S-EPMC9894357biostudies-literatureUnknown7(2)<h4>Background and aims</h4>The NAFLD activity score was developed to measure histologic changes in NAFLD during therapeutic trials. Hepatocyte ballooning (HB) is the most specific feature in steatohepatitis diagnosis, yet the impact of variations in HB has not been incorporated.<h4>Approach and results</h4>Liver biopsies from patients enrolled in the NASH Clinical Research Network with an initial diagnosis of NASH or NAFL (n=1688) were evaluated to distinguish classic hepatocyte ballooning (cHB) from smaller, nonclassic hepatocyte ballooning (nHB), and also to designate severe ballooning and assign an extended hepatocyte ballooning (eB) score [0 points, no ballooning (NB); 1 point, few or many nHB; 2 points, few cHB; 3 points, many cHB; 4 points, severe cHB] to the biopsy assessment. The Hepatology communicationsThe nonalcoholic steatohepatitis extended hepatocyte ballooning score: histologic classification and clinical significance.PMC9894357U24 DK061730UL1 TR000058UL1 TR000100UL1 TR000006UL1 TR000436U01 DK061732UL1 TR000004U01 DK061713UL1 TR000423U01 DK061734UL1 TR000439U01 DK061731UL1 TR000448U01 DK061730U01 DK061718U01 DK061737U01 DK061728U01 DK061738Tonascia JVan Natta MLGuy CDCarpenter DYamada GKleiner DEGill RMNonalcoholic Steatohepatitis Clinical Research Network (NASH CRN)Neuschwander-Tetri BABelt PHBehling CACummings OWSanyal AJWilson LAAllende DYeh MfalseThe nonalcoholic steatohepatitis extended hepatocyte ballooning score: histologic classification and clinical significance.<h4>Background and aims</h4>The NAFLD activity score was developed to measure histologic changes in NAFLD during therapeutic trials. Hepatocyte ballooning (HB) is the most specific feature in steatohepatitis diagnosis, yet the impact of variations in HB has not been incorporated.<h4>Approach and results</h4>Liver biopsies from patients enrolled in the NASH Clinical Research Network with an initial diagnosis of NASH or NAFL (n=1688) were evaluated to distinguish classic hepatocyte ballooning (cHB) from smaller, nonclassic hepatocyte ballooning (nHB), and also to designate severe ballooning and assign an extended hepatocyte ballooning (eB) score [0 points, no ballooning (NB); 1 point, few or many nHB; 2 points, few cHB; 3 points, many cHB; 4 points, severe cHB] to the biopsy assessment. The 2023-01-01T00:00:00Z2023 Feb2026-06-13T06:11:44.733Z2025-02-19T02:22:57.791ZS-EPMC98943573672412710.1097/HC9.0000000000000033