biostudies-literatureJun Mschool of medicine, stanford universitye0276651https://www.ebi.ac.uk/biostudies/studies/S-EPMC9894485biostudies-literatureUnknown18(2)<h4>Objectives</h4>A phase II = design is used to evaluate the efficacy and feasibility of full dose docetaxel, platinum, and 5-fluorouracil (TPF) in a sequential chemoradiation treatment locally advanced (LA) or oligometastatic (OM) NPC patients.<h4>Materials and methods</h4>Twenty patients with LANPC (M0 cohort) and six patients with OMNPC (M1 cohort) received induction standard dose T (75 mg/m2) P (75 mg/m2) F (750 mg/m2 IVCI x 5days) x 3 followed by weekly cisplatin (40 mg/m2) or carboplatin (AUC 1.5) x 6 concurrent with radiation therapy of 70 Gy over 6.5-7 weeks. The first five patients received bevacizumab as part of an exploratory objective of hypoxia modification using correlative fluoromisonidasole (18F-MISO) PET CT scanning.<h4>Results</h4>The 18F-MISO imaging failed to reveal aPloS oneIn search for optimal induction chemotherapy for advanced nasopharyngeal cancer: Standard dosing of Docetaxel, Platinum, and 5-Fluorouracil (TPF) followed by chemoradiation.PMC9894485[1105753 310 GHAQY].Colevas ADMcMillan AWinters ELira RHara WLe QTJun MQuon APinto HCoty JLu RfalseIn search for optimal induction chemotherapy for advanced nasopharyngeal cancer: Standard dosing of Docetaxel, Platinum, and 5-Fluorouracil (TPF) followed by chemoradiation.<h4>Objectives</h4>A phase II = design is used to evaluate the efficacy and feasibility of full dose docetaxel, platinum, and 5-fluorouracil (TPF) in a sequential chemoradiation treatment locally advanced (LA) or oligometastatic (OM) NPC patients.<h4>Materials and methods</h4>Twenty patients with LANPC (M0 cohort) and six patients with OMNPC (M1 cohort) received induction standard dose T (75 mg/m2) P (75 mg/m2) F (750 mg/m2 IVCI x 5days) x 3 followed by weekly cisplatin (40 mg/m2) or carboplatin (AUC 1.5) x 6 concurrent with radiation therapy of 70 Gy over 6.5-7 weeks. The first five patients received bevacizumab as part of an exploratory objective of hypoxia modification using correlative fluoromisonidasole (18F-MISO) PET CT scanning.<h4>Results</h4>The 18F-MISO imaging failed to reveal a2023-01-01T00:00:00Z20232026-05-28T19:00:49.438Z2025-02-19T00:13:36.797ZS-EPMC98944853673014510.1371/journal.pone.0276651