biostudies-literatureGzielo KNarodowe Centrum NaukiMaj Institute of Pharmacology, Polish Academy of Sciences1918https://www.ebi.ac.uk/biostudies/studies/S-EPMC9894913biostudies-literatureUnknown13(1)A wide body of evidence suggests a relationship between maternal immune activation (MIA) and neurodevelopmental disorders such as autism spectrum disorder (ASD). Since social and communicative deficits are included in the first diagnostic criterion of ASD, we aimed to characterize socio-communicative behaviors in the MIA model based on prenatal exposure to poly(I:C). Our previous studies demonstrated impaired socio-communicative functioning in poly(I:C)-exposed adolescent rats. Therefore, the current study sought to clarify whether these changes would persist beyond adolescence. For this purpose, we analyzed behavior during the social interaction test and recorded ultrasonic vocalizations (USVs) accompanying interactions between adult poly(I:C) rats. The results demonstrated that the alterScientific reportsMaternal immune activation affects socio-communicative behavior in adult rats.PMC9894913Statutory funds2016/23/B/NZ7/01131Nikiforuk ALitwa EGzielo KPopik PPiotrowska DfalseMaternal immune activation affects socio-communicative behavior in adult rats.A wide body of evidence suggests a relationship between maternal immune activation (MIA) and neurodevelopmental disorders such as autism spectrum disorder (ASD). Since social and communicative deficits are included in the first diagnostic criterion of ASD, we aimed to characterize socio-communicative behaviors in the MIA model based on prenatal exposure to poly(I:C). Our previous studies demonstrated impaired socio-communicative functioning in poly(I:C)-exposed adolescent rats. Therefore, the current study sought to clarify whether these changes would persist beyond adolescence. For this purpose, we analyzed behavior during the social interaction test and recorded ultrasonic vocalizations (USVs) accompanying interactions between adult poly(I:C) rats. The results demonstrated that the alter2023-01-01T00:00:00Z2023 Feb2025-04-22T18:11:40.936Z2025-04-06T02:23:26.337ZS-EPMC98949133673257910.1038/s41598-023-28919-z