biostudies-literatureUnknown47(3)Yoh T<h4>Backgrounds</h4>In the era of multidisciplinary treatment strategy, resectability for hepatocellular carcinoma (HCC) should be defined. This study aimed to propose and validate a resectability classification of HCC.<h4>Methods</h4>We proposed following the three groups; resectable-(R), borderline resectable-(BR), and unresectable (UR)-HCCs. Resectable two groups were sub-divided according to the value of indocyanine green clearance of remnant liver (ICG-Krem) and presence of macrovascular invasion (MVI); BR-HCC was defined as resectable HCCs with MVI and/or ICG-Krem≥0.03-<0.05, and R-HCC was the remaining. Consecutive patients with HCC who underwent liver resection (LR) and non-surgical treatment(s) (i.e., UR-HCC) between 2011 and 2017 were retrospectively analyzed to validate the propWorld journal of surgery740-748https://www.ebi.ac.uk/biostudies/studies/S-EPMC9895025biostudies-literatureA Conceptual Classification of Resectability for Hepatocellular Carcinoma.PMC9895025Seo SHatano EIto TFukumitsu KNishio THata KKoyama YYoh TIshii TOgiso SUchida YfalseA Conceptual Classification of Resectability for Hepatocellular Carcinoma.<h4>Backgrounds</h4>In the era of multidisciplinary treatment strategy, resectability for hepatocellular carcinoma (HCC) should be defined. This study aimed to propose and validate a resectability classification of HCC.<h4>Methods</h4>We proposed following the three groups; resectable-(R), borderline resectable-(BR), and unresectable (UR)-HCCs. Resectable two groups were sub-divided according to the value of indocyanine green clearance of remnant liver (ICG-Krem) and presence of macrovascular invasion (MVI); BR-HCC was defined as resectable HCCs with MVI and/or ICG-Krem≥0.03-<0.05, and R-HCC was the remaining. Consecutive patients with HCC who underwent liver resection (LR) and non-surgical treatment(s) (i.e., UR-HCC) between 2011 and 2017 were retrospectively analyzed to validate the prop2023-01-01T00:00:00Z2023 Mar2025-04-22T18:11:23.014Z2025-04-06T02:23:18.511ZS-EPMC98950253628726610.1007/s00268-022-06803-7