{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Veronese N"],"funding":["Medical Research Council","Università degli Studi di Palermo","National Institute for Health Research (NIHR)","King Saud University"],"pagination":["245-252"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9895027"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["35(2)"],"pubmed_abstract":["<h4>Background</h4>Knee osteoarthritis (OA) is a common condition, associated with a high rate of disability and poor quality of life. Despite the importance of such evidence in public health, no umbrella review (i.e., a review of other systematic reviews and meta-analyses) has systematically assessed evidence on association between knee OA and adverse health outcomes.<h4>Aims</h4>To map and grade all health outcomes associated with knee OA using an umbrella review approach.<h4>Methods</h4>The search was made across several databases up to 22 April 2022. We used an umbrella review of systematic reviews with meta-analyses of observational studies assessing the effect sizes, based on random effect summary, 95% prediction intervals, heterogeneity, small study effects, and excess significance "],"journal":["Aging clinical and experimental research"],"pubmed_title":["Knee osteoarthritis and adverse health outcomes: an umbrella review of meta-analyses of observational studies."],"pmcid":["PMC9895027"],"funding_grant_id":["MC_U147585819","MC_UP_A620_1014","MC_U147585824","MC_UP_A620_1015","U1475000001","MC_U147585827","MC_PC_21003","NF-SI-0508-10082","MC_UU_12011/2","G0400491","MC_PC_21001","MC_UU_12011/1","NF-SI-0513-10085","MC_PC_21022","MC_PC_21000"],"pubmed_authors":["Bruyere O","Pegreffi F","Al-Daghri N","Honvo G","Barbagallo M","Maggi S","Rizzoli R","Sabico S","Cooper C","Reginster JY","Veronese N","Smith L"],"additional_accession":[]},"is_claimable":false,"name":"Knee osteoarthritis and adverse health outcomes: an umbrella review of meta-analyses of observational studies.","description":"<h4>Background</h4>Knee osteoarthritis (OA) is a common condition, associated with a high rate of disability and poor quality of life. Despite the importance of such evidence in public health, no umbrella review (i.e., a review of other systematic reviews and meta-analyses) has systematically assessed evidence on association between knee OA and adverse health outcomes.<h4>Aims</h4>To map and grade all health outcomes associated with knee OA using an umbrella review approach.<h4>Methods</h4>The search was made across several databases up to 22 April 2022. We used an umbrella review of systematic reviews with meta-analyses of observational studies assessing the effect sizes, based on random effect summary, 95% prediction intervals, heterogeneity, small study effects, and excess significance ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2026-03-17T15:43:39.797Z","creation":"2025-04-06T14:06:46.444Z"},"accession":"S-EPMC9895027","cross_references":{"pubmed":["36331799"],"doi":["10.1007/s40520-022-02289-4"]}}