biostudies-literatureVeronese NMedical Research CouncilUniversità degli Studi di PalermoNational Institute for Health Research (NIHR)King Saud University245-252https://www.ebi.ac.uk/biostudies/studies/S-EPMC9895027biostudies-literatureUnknown35(2)<h4>Background</h4>Knee osteoarthritis (OA) is a common condition, associated with a high rate of disability and poor quality of life. Despite the importance of such evidence in public health, no umbrella review (i.e., a review of other systematic reviews and meta-analyses) has systematically assessed evidence on association between knee OA and adverse health outcomes.<h4>Aims</h4>To map and grade all health outcomes associated with knee OA using an umbrella review approach.<h4>Methods</h4>The search was made across several databases up to 22 April 2022. We used an umbrella review of systematic reviews with meta-analyses of observational studies assessing the effect sizes, based on random effect summary, 95% prediction intervals, heterogeneity, small study effects, and excess significance Aging clinical and experimental researchKnee osteoarthritis and adverse health outcomes: an umbrella review of meta-analyses of observational studies.PMC9895027MC_U147585819MC_UP_A620_1014MC_U147585824MC_UP_A620_1015U1475000001MC_U147585827MC_PC_21003NF-SI-0508-10082MC_UU_12011/2G0400491MC_PC_21001MC_UU_12011/1NF-SI-0513-10085MC_PC_21022MC_PC_21000Bruyere OPegreffi FAl-Daghri NHonvo GBarbagallo MMaggi SRizzoli RSabico SCooper CReginster JYVeronese NSmith LfalseKnee osteoarthritis and adverse health outcomes: an umbrella review of meta-analyses of observational studies.<h4>Background</h4>Knee osteoarthritis (OA) is a common condition, associated with a high rate of disability and poor quality of life. Despite the importance of such evidence in public health, no umbrella review (i.e., a review of other systematic reviews and meta-analyses) has systematically assessed evidence on association between knee OA and adverse health outcomes.<h4>Aims</h4>To map and grade all health outcomes associated with knee OA using an umbrella review approach.<h4>Methods</h4>The search was made across several databases up to 22 April 2022. We used an umbrella review of systematic reviews with meta-analyses of observational studies assessing the effect sizes, based on random effect summary, 95% prediction intervals, heterogeneity, small study effects, and excess significance 2023-01-01T00:00:00Z2023 Feb2026-03-17T15:43:39.797Z2025-04-06T14:06:46.444ZS-EPMC98950273633179910.1007/s40520-022-02289-4