{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Meng XL"],"funding":["Innovative Research Group Project of the National Natural Science Foundation of China","Key Technologies Research and Development Program","the Shanghai Municipal Natural Science Foundation","the Key Disease Joint Research Program of Xuhui District","Sanming Project of Medicine in Shenzhen","the Clinical Research Plan of SHDC","National College Students Innovation and Entrepreneurship Training Program","Beijing Mutual Care Public Welfare Foundation"],"pagination":["63-76"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9895046"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(1)"],"pubmed_abstract":["<h4>Background</h4>Perineural invasion (PNI) is associated with metastasis in malignancies, including intrahepatic cholangiocarcinoma (ICC), and is correlated with poor prognosis.<h4>Methods</h4>The study included three large cohorts: ZS-ICC and TMA cohorts from our team, MSK cohort from a public database, and a small cohort named cohort 4. Prognostic implications of PNI were investigated in MSK cohort and TMA cohort. PNI-related genomic and transcriptomic profiles were analyzed in MSK and ZS-ICC cohorts. GO, KEGG, and ssGSEA analyses were performed. Immunohistochemistry was used to investigate the relationship between PNI and markers of neurons, hydrolases, and immune cells. The efficacy of adjuvant therapy in ICC patients with PNI was also assessed.<h4>Results</h4>A total of 30.6% and 20.7% ICC patients had PNI in MSK and TMA cohorts respectively. Patients with PNI presented with malignant phenotypes such as high CA19-9, the large bile duct type, lymph node invasion, and shortened overall survival (OS) and relapse-free survival (RFS). Nerves involved in PNI positively express tyrosine hydroxylase (TH), a marker of sympathetic nerves. Patients with PNI showed high mutation frequency of KRAS and an immune suppressive metastasis prone niche of decreased NK cell, increased neutrophil, and elevated PD-L1, CD80, and CD86 expression. Patients with PNI had an extended OS after adjuvant therapy with TEGIO, GEMOX, or capecitabine.<h4>Conclusion</h4>Our study deciphered the genomic features and the immune suppressive metastasis-prone niche in ICC with PNI. Patients with PNI showed a poor prognosis after surgery but a good response to adjuvant chemotherapy."],"journal":["Hepatology international"],"pubmed_title":["The clinical implications and molecular features of intrahepatic cholangiocarcinoma with perineural invasion."],"pmcid":["PMC9895046"],"funding_grant_id":["GDXZ-08-05","81972232","No. SZSM202003009","20JC1419103","202210246001S","XHLHGG202103","2019YFC1316000","SHDC‑2020CR1003A"],"pubmed_authors":["Yv L","Huang XY","Zeng HY","Huang PX","Zhang L","Gao C","Pei YZ","Yang GH","Ye M","Ke AW","Lu JC","Meng XL","Chen Z","Hu SY","Sun QM","Fan J","Cai JB","Shi YH","Guo XJ","Chen Y","Shi GM","Zhou J"],"additional_accession":[]},"is_claimable":false,"name":"The clinical implications and molecular features of intrahepatic cholangiocarcinoma with perineural invasion.","description":"<h4>Background</h4>Perineural invasion (PNI) is associated with metastasis in malignancies, including intrahepatic cholangiocarcinoma (ICC), and is correlated with poor prognosis.<h4>Methods</h4>The study included three large cohorts: ZS-ICC and TMA cohorts from our team, MSK cohort from a public database, and a small cohort named cohort 4. Prognostic implications of PNI were investigated in MSK cohort and TMA cohort. PNI-related genomic and transcriptomic profiles were analyzed in MSK and ZS-ICC cohorts. GO, KEGG, and ssGSEA analyses were performed. Immunohistochemistry was used to investigate the relationship between PNI and markers of neurons, hydrolases, and immune cells. The efficacy of adjuvant therapy in ICC patients with PNI was also assessed.<h4>Results</h4>A total of 30.6% and 20.7% ICC patients had PNI in MSK and TMA cohorts respectively. Patients with PNI presented with malignant phenotypes such as high CA19-9, the large bile duct type, lymph node invasion, and shortened overall survival (OS) and relapse-free survival (RFS). Nerves involved in PNI positively express tyrosine hydroxylase (TH), a marker of sympathetic nerves. Patients with PNI showed high mutation frequency of KRAS and an immune suppressive metastasis prone niche of decreased NK cell, increased neutrophil, and elevated PD-L1, CD80, and CD86 expression. Patients with PNI had an extended OS after adjuvant therapy with TEGIO, GEMOX, or capecitabine.<h4>Conclusion</h4>Our study deciphered the genomic features and the immune suppressive metastasis-prone niche in ICC with PNI. Patients with PNI showed a poor prognosis after surgery but a good response to adjuvant chemotherapy.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-05-29T19:45:34.601Z","creation":"2025-05-29T19:45:34.601Z"},"accession":"S-EPMC9895046","cross_references":{"pubmed":["36418844"],"doi":["10.1007/s12072-022-10445-1"]}}