{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gilbert AK"],"funding":["National Institutes of Health","NIGMS NIH HHS","National Science Foundation"],"pagination":["17651-17660"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9896967"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["144(38)"],"pubmed_abstract":["Hydrogen sulfide (H<sub>2</sub>S) is an endogenously produced gaseous signaling molecule with important roles in regulating organelle function and stress. Because of its high reactivity, targeted delivery of H<sub>2</sub>S using small molecule H<sub>2</sub>S donors has garnered significant interest to minimize off-target effects. Although mitochondrially targeted H<sub>2</sub>S donors, such as AP39, have been reported previously and exhibit significantly higher potency than nontargeted donors, the expansion of targeted H<sub>2</sub>S delivery to other subcellular organelles remains largely absent. To fill this key unmet need, we report a library of organelle-targeted H<sub>2</sub>S donors that localize H<sub>2</sub>S delivery to specific subcellular organelles, including the Golgi apparatu"],"journal":["Journal of the American Chemical Society"],"pubmed_title":["Subcellular Delivery of Hydrogen Sulfide Using Small Molecule Donors Impacts Organelle Stress."],"pmcid":["PMC9896967"],"funding_grant_id":["R01GM113030","DGE-1842486","R01 GM113030"],"pubmed_authors":["Pluth MD","Gilbert AK"],"additional_accession":[]},"is_claimable":false,"name":"Subcellular Delivery of Hydrogen Sulfide Using Small Molecule Donors Impacts Organelle Stress.","description":"Hydrogen sulfide (H<sub>2</sub>S) is an endogenously produced gaseous signaling molecule with important roles in regulating organelle function and stress. Because of its high reactivity, targeted delivery of H<sub>2</sub>S using small molecule H<sub>2</sub>S donors has garnered significant interest to minimize off-target effects. Although mitochondrially targeted H<sub>2</sub>S donors, such as AP39, have been reported previously and exhibit significantly higher potency than nontargeted donors, the expansion of targeted H<sub>2</sub>S delivery to other subcellular organelles remains largely absent. To fill this key unmet need, we report a library of organelle-targeted H<sub>2</sub>S donors that localize H<sub>2</sub>S delivery to specific subcellular organelles, including the Golgi apparatu","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-03T23:17:23.407Z","creation":"2025-04-03T23:17:23.407Z"},"accession":"S-EPMC9896967","cross_references":{"pubmed":["36121306"],"doi":["10.1021/jacs.2c07225"]}}