biostudies-literatureGilbert AKNational Institutes of HealthNIGMS NIH HHSNational Science Foundation17651-17660https://www.ebi.ac.uk/biostudies/studies/S-EPMC9896967biostudies-literatureUnknown144(38)Hydrogen sulfide (H<sub>2</sub>S) is an endogenously produced gaseous signaling molecule with important roles in regulating organelle function and stress. Because of its high reactivity, targeted delivery of H<sub>2</sub>S using small molecule H<sub>2</sub>S donors has garnered significant interest to minimize off-target effects. Although mitochondrially targeted H<sub>2</sub>S donors, such as AP39, have been reported previously and exhibit significantly higher potency than nontargeted donors, the expansion of targeted H<sub>2</sub>S delivery to other subcellular organelles remains largely absent. To fill this key unmet need, we report a library of organelle-targeted H<sub>2</sub>S donors that localize H<sub>2</sub>S delivery to specific subcellular organelles, including the Golgi apparatuJournal of the American Chemical SocietySubcellular Delivery of Hydrogen Sulfide Using Small Molecule Donors Impacts Organelle Stress.PMC9896967R01GM113030DGE-1842486R01 GM113030Pluth MDGilbert AKfalseSubcellular Delivery of Hydrogen Sulfide Using Small Molecule Donors Impacts Organelle Stress.Hydrogen sulfide (H<sub>2</sub>S) is an endogenously produced gaseous signaling molecule with important roles in regulating organelle function and stress. Because of its high reactivity, targeted delivery of H<sub>2</sub>S using small molecule H<sub>2</sub>S donors has garnered significant interest to minimize off-target effects. Although mitochondrially targeted H<sub>2</sub>S donors, such as AP39, have been reported previously and exhibit significantly higher potency than nontargeted donors, the expansion of targeted H<sub>2</sub>S delivery to other subcellular organelles remains largely absent. To fill this key unmet need, we report a library of organelle-targeted H<sub>2</sub>S donors that localize H<sub>2</sub>S delivery to specific subcellular organelles, including the Golgi apparatu2022-01-01T00:00:00Z2022 Sep2025-04-03T23:17:23.407Z2025-04-03T23:17:23.407ZS-EPMC98969673612130610.1021/jacs.2c07225