biostudies-literaturePadula WVBill &amp; Melinda Gates FoundationNCATS NIH HHSNational Institutes of Health1060-1069https://www.ebi.ac.uk/biostudies/studies/S-EPMC9897209biostudies-literatureUnknown24(1)<h4>Aims</h4>The Novel Coronavirus (COVID-19) has infected over two hundred million worldwide and caused 4.4 million of deaths as of August 2021. Vaccines were quickly developed to address the pandemic. We sought to analyze the cost-effectiveness and budget impact of a non-specified vaccine for COVID-19.<h4>Materials and methods</h4>We constructed a Markov model of COVID-19 infections using a susceptible-exposed-infected-recovered structure over a 1-year time horizon from a U.S. healthcare sector perspective. The model consisted of two arms: do nothing and COVID-19 vaccine. Hospitalization and mortality rates were calibrated to U.S. COVID-19 reports as of November 2020. We performed economic calculations of costs in 2020 U.S. dollars and effectiveness in units of quality-adjusted life yearJournal of medical economicsEconomic value of vaccines to address the COVID-19 pandemic: a U.S. cost-effectiveness and budget impact analysis.PMC9897209KL2 TR001854Padula WVTierce JChingcuanco FMalaviya SBallreich JCohen BGAlexander GCReid NMfalseEconomic value of vaccines to address the COVID-19 pandemic: a U.S. cost-effectiveness and budget impact analysis.<h4>Aims</h4>The Novel Coronavirus (COVID-19) has infected over two hundred million worldwide and caused 4.4 million of deaths as of August 2021. Vaccines were quickly developed to address the pandemic. We sought to analyze the cost-effectiveness and budget impact of a non-specified vaccine for COVID-19.<h4>Materials and methods</h4>We constructed a Markov model of COVID-19 infections using a susceptible-exposed-infected-recovered structure over a 1-year time horizon from a U.S. healthcare sector perspective. The model consisted of two arms: do nothing and COVID-19 vaccine. Hospitalization and mortality rates were calibrated to U.S. COVID-19 reports as of November 2020. We performed economic calculations of costs in 2020 U.S. dollars and effectiveness in units of quality-adjusted life year2021-01-01T00:00:00Z2021 Jan-Dec2026-03-17T15:58:51.549Z2025-02-19T04:20:51.26ZS-EPMC98972093435784310.1080/13696998.2021.1965732