biostudies-literatureSetinc MCroatian Science Foundatione0279971https://www.ebi.ac.uk/biostudies/studies/S-EPMC9897585biostudies-literatureUnknown18(2)Longevity is a hallmark of successful ageing and a complex trait with a significant genetic component. In this study, 43 single nucleotide polymorphisms (SNPs) were chosen from the literature and genotyped in a Croatian oldest-old sample (85+ years, sample size (N) = 314), in order to determine whether any of these SNPs have a significant effect on reaching the age thresholds for longevity (90+ years, N = 212) and extreme longevity (95+ years, N = 84). The best models were selected for both survival ages using multivariate logistic regression. In the model for reaching age 90, nine SNPs explained 20% of variance for survival to that age, while the 95-year model included five SNPs accounting for 9.3% of variance. The two SNPs that showed the most significant association (p ≤ 0.01) with longPloS oneGenetic scores for predicting longevity in the Croatian oldest-old population.PMC9897585IP-01-2018-2497 (HECUBA project) and DOK-2018-09-8382Smolej Narancic NPericic Salihovic MSkaric-Juric TStojanovic Markovic ACoric TKolaric BCelinscak ZZajc Petranovic MSetinc MBockor LfalseGenetic scores for predicting longevity in the Croatian oldest-old population.Longevity is a hallmark of successful ageing and a complex trait with a significant genetic component. In this study, 43 single nucleotide polymorphisms (SNPs) were chosen from the literature and genotyped in a Croatian oldest-old sample (85+ years, sample size (N) = 314), in order to determine whether any of these SNPs have a significant effect on reaching the age thresholds for longevity (90+ years, N = 212) and extreme longevity (95+ years, N = 84). The best models were selected for both survival ages using multivariate logistic regression. In the model for reaching age 90, nine SNPs explained 20% of variance for survival to that age, while the 95-year model included five SNPs accounting for 9.3% of variance. The two SNPs that showed the most significant association (p ≤ 0.01) with long2023-01-01T00:00:00Z20232026-05-28T19:00:45.46Z2025-02-19T00:13:30.528ZS-EPMC98975853673572010.1371/journal.pone.0279971