biostudies-literatureWagle NSNIMHD NIH HHSNCI NIH HHSNIH1281-1292.e10https://www.ebi.ac.uk/biostudies/studies/S-EPMC9898458biostudies-literatureUnknown21(5)<h4>Background & aims</h4>Failures have been reported across the cancer care continuum in patients with hepatocellular carcinoma (HCC); however, the impact of treatment delays on outcomes has not been well-characterized. We described the prevalence of treatment delays in a racially and ethnically diverse cohort of patients and its association with overall survival.<h4>Methods</h4>Using the Surveillance, Epidemiology, and End Results-Medicare database, we identified patients diagnosed with HCC between 2001 and 2015. We performed multivariable logistic regression analysis to identify factors associated with treatment delay (ie, receipt of HCC-directed therapy >3 months after diagnosis). Cox proportional hazards regression analysis with a 5-month landmark was used to characterize the associatClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological AssociationRacial, Ethnic, and Socioeconomic Disparities in Treatment Delay Among Patients With Hepatocellular Carcinoma in the United States.PMC9898458R01 CA256977R01 MD012565Washburn DOhsfeldt RLRich NEKum HCSingal AGWagle NSPark SfalseRacial, Ethnic, and Socioeconomic Disparities in Treatment Delay Among Patients With Hepatocellular Carcinoma in the United States.<h4>Background & aims</h4>Failures have been reported across the cancer care continuum in patients with hepatocellular carcinoma (HCC); however, the impact of treatment delays on outcomes has not been well-characterized. We described the prevalence of treatment delays in a racially and ethnically diverse cohort of patients and its association with overall survival.<h4>Methods</h4>Using the Surveillance, Epidemiology, and End Results-Medicare database, we identified patients diagnosed with HCC between 2001 and 2015. We performed multivariable logistic regression analysis to identify factors associated with treatment delay (ie, receipt of HCC-directed therapy >3 months after diagnosis). Cox proportional hazards regression analysis with a 5-month landmark was used to characterize the associat2023-01-01T00:00:00Z2023 May2025-04-18T15:30:14.904Z2025-04-07T02:12:29.326ZS-EPMC98984583593307610.1016/j.cgh.2022.07.031