{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Akiyama M"],"funding":["Japan Agency for Medical Research and Development"],"pagination":["143"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9898503"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(1)"],"pubmed_abstract":["Human lifespan is reported to be heritable. Although previous genome-wide association studies (GWASs) have identified several loci, a limited number of studies have assessed the genetic associations with the real survival information on the participants. We conducted a GWAS to identify loci associated with survival time in the Japanese individuals participated in the BioBank Japan Project by carrying out sex-stratified GWASs involving 78,029 males and 59,664 females. Of them, 31,324 (22.7%) died during the mean follow-up period of 7.44 years. We found a novel locus associated with survival (BET1L; P = 5.89 × 10<sup>-9</sup>). By integrating with eQTL data, we detected a significant overlap with eQTL of BET1L in skeletal muscle. A gene-set enrichment analysis showed that genes related to th"],"journal":["Communications biology"],"pubmed_title":["Genome-wide association study reveals BET1L associated with survival time in the 137,693 Japanese individuals."],"pmcid":["PMC9898503"],"funding_grant_id":["JP21zf0127003"],"pubmed_authors":["Kamatani Y","Murakami Y","Morisaki T","Sakaue S","Takahashi A","Koido M","Terao C","Ishigaki K","Sagiya Y","Hirata M","Biobank Japan project","Okada Y","Ninomiya T","Akiyama M","Nagai A","Momozawa Y","Matsuda K","Kubo M"],"additional_accession":[]},"is_claimable":false,"name":"Genome-wide association study reveals BET1L associated with survival time in the 137,693 Japanese individuals.","description":"Human lifespan is reported to be heritable. Although previous genome-wide association studies (GWASs) have identified several loci, a limited number of studies have assessed the genetic associations with the real survival information on the participants. We conducted a GWAS to identify loci associated with survival time in the Japanese individuals participated in the BioBank Japan Project by carrying out sex-stratified GWASs involving 78,029 males and 59,664 females. Of them, 31,324 (22.7%) died during the mean follow-up period of 7.44 years. We found a novel locus associated with survival (BET1L; P = 5.89 × 10<sup>-9</sup>). By integrating with eQTL data, we detected a significant overlap with eQTL of BET1L in skeletal muscle. A gene-set enrichment analysis showed that genes related to th","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2026-05-29T03:42:47.02Z","creation":"2024-10-18T17:36:03.429Z"},"accession":"S-EPMC9898503","cross_references":{"pubmed":["36737517"],"doi":["10.1038/s42003-023-04491-0"]}}