biostudies-literatureAkiyama MJapan Agency for Medical Research and Development143https://www.ebi.ac.uk/biostudies/studies/S-EPMC9898503biostudies-literatureUnknown6(1)Human lifespan is reported to be heritable. Although previous genome-wide association studies (GWASs) have identified several loci, a limited number of studies have assessed the genetic associations with the real survival information on the participants. We conducted a GWAS to identify loci associated with survival time in the Japanese individuals participated in the BioBank Japan Project by carrying out sex-stratified GWASs involving 78,029 males and 59,664 females. Of them, 31,324 (22.7%) died during the mean follow-up period of 7.44 years. We found a novel locus associated with survival (BET1L; P = 5.89 × 10^-9). By integrating with eQTL data, we detected a significant overlap with eQTL of BET1L in skeletal muscle. A gene-set enrichment analysis showed that genes related to thCommunications biologyGenome-wide association study reveals BET1L associated with survival time in the 137,693 Japanese individuals.PMC9898503JP21zf0127003Kamatani YMurakami YMorisaki TSakaue STakahashi AKoido MTerao CIshigaki KSagiya YHirata MBiobank Japan projectOkada YNinomiya TAkiyama MNagai AMomozawa YMatsuda KKubo MfalseGenome-wide association study reveals BET1L associated with survival time in the 137,693 Japanese individuals.Human lifespan is reported to be heritable. Although previous genome-wide association studies (GWASs) have identified several loci, a limited number of studies have assessed the genetic associations with the real survival information on the participants. We conducted a GWAS to identify loci associated with survival time in the Japanese individuals participated in the BioBank Japan Project by carrying out sex-stratified GWASs involving 78,029 males and 59,664 females. Of them, 31,324 (22.7%) died during the mean follow-up period of 7.44 years. We found a novel locus associated with survival (BET1L; P = 5.89 × 10^-9). By integrating with eQTL data, we detected a significant overlap with eQTL of BET1L in skeletal muscle. A gene-set enrichment analysis showed that genes related to th2023-01-01T00:00:00Z2023 Feb2026-05-29T03:42:47.02Z2024-10-18T17:36:03.429ZS-EPMC98985033673751710.1038/s42003-023-04491-0