biostudies-literatureClemmer JSU.S. Department of Health & Human Services | NIH | National Institute of General Medical SciencesNHLBI NIH HHSNIMHD NIH HHSU.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood InstituteU.S. Department of Health & Human Services | NIH | National Institute on Minority Health and Health DisparitiesNIGMS NIH HHS300-306https://www.ebi.ac.uk/biostudies/studies/S-EPMC9899545biostudies-literatureUnknown37(4)Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disorder that primarily affects women of childbearing age. While immune system dysfunction has been implicated in the development of hypertension (HTN) in SLE, the effect of immunomodulatory drugs on blood pressure (BP) control in SLE patients is unknown. In the present study, we hypothesized that first-line immunomodulatory therapies prescribed to SLE patients would have a beneficial impact on BP. We retrospectively analyzed the Research Data Warehouse containing de-identified patient data (n = 1,075,406) from the University of Mississippi Medical Center for all patients with a clinical diagnosis of SLE. BP responses were analyzed in SLE patients that were initially prescribed a single therapy (methotrexate, hydroxychlJournal of human hypertensionAntihypertensive effects of immunosuppressive therapy in autoimmune disease.PMC9899545K99 MD014738P01 HL051971P20 GM104357R00 HL146888U54 GM115428K99 HL146888R00 MD014738Clemmer JSHillegass WBTaylor EBfalseAntihypertensive effects of immunosuppressive therapy in autoimmune disease.Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disorder that primarily affects women of childbearing age. While immune system dysfunction has been implicated in the development of hypertension (HTN) in SLE, the effect of immunomodulatory drugs on blood pressure (BP) control in SLE patients is unknown. In the present study, we hypothesized that first-line immunomodulatory therapies prescribed to SLE patients would have a beneficial impact on BP. We retrospectively analyzed the Research Data Warehouse containing de-identified patient data (n = 1,075,406) from the University of Mississippi Medical Center for all patients with a clinical diagnosis of SLE. BP responses were analyzed in SLE patients that were initially prescribed a single therapy (methotrexate, hydroxychl2023-01-01T00:00:00Z2023 Apr2025-04-04T03:00:30.443Z2025-04-04T03:00:30.443ZS-EPMC98995453539653610.1038/s41371-022-00682-0