biostudies-literatureWatling CZWorld Cancer Research FundNuffield Department of Population Health Intermediate FellowshipOxford and Thames Valley NIHR Applied Research Centre and the Ramon y Cajal FellowshipGirdlers’ New Zealand Health Research Council FellowshipCancer Research UKClarendon ScholarshipMedical Research CouncilNuffield Department of Population HealthWellcome Trust115-124https://www.ebi.ac.uk/biostudies/studies/S-EPMC9899744biostudies-literatureUnknown62(1)<h4>Purpose</h4>Circulating insulin-like growth factor-I (IGF-I) concentrations have been positively associated with risk of several common cancers and inversely associated with risk of bone fractures. Intakes of some foods have been associated with increased circulating IGF-I concentrations; however, evidence remains inconclusive. Our aim was to assess cross-sectional associations of food group intakes with circulating IGF-I concentrations in the UK Biobank.<h4>Methods</h4>At recruitment, the UK Biobank participants reported their intake of commonly consumed foods. From these questions, intakes of total vegetables, fresh fruit, red meat, processed meat, poultry, oily fish, non-oily fish, and cheese were estimated. Serum IGF-I concentrations were measured in blood samples collected at recrEuropean journal of nutritionAssociations between food group intakes and circulating insulin-like growth factor-I in the UK Biobank: a cross-sectional analysis.PMC9899744C60192/A28516MC_PC_1722819/031205212290172019/1953MR/M012190/1MC_UU_00019/4205212/Z/16/ZMC_UU_00019/2MC_QA137853C8221/A29017Watling CZWatts ELPerez-Cornago AKnuppel AKey TJKelly RKSchmidt JAPiernas CTong TYNTravis RCTin Tin SfalseAssociations between food group intakes and circulating insulin-like growth factor-I in the UK Biobank: a cross-sectional analysis.<h4>Purpose</h4>Circulating insulin-like growth factor-I (IGF-I) concentrations have been positively associated with risk of several common cancers and inversely associated with risk of bone fractures. Intakes of some foods have been associated with increased circulating IGF-I concentrations; however, evidence remains inconclusive. Our aim was to assess cross-sectional associations of food group intakes with circulating IGF-I concentrations in the UK Biobank.<h4>Methods</h4>At recruitment, the UK Biobank participants reported their intake of commonly consumed foods. From these questions, intakes of total vegetables, fresh fruit, red meat, processed meat, poultry, oily fish, non-oily fish, and cheese were estimated. Serum IGF-I concentrations were measured in blood samples collected at recr2023-01-01T00:00:00Z2023 Feb2026-07-14T15:45:43.372Z2025-04-20T03:39:02.832ZS-EPMC98997443590635710.1007/s00394-022-02954-4