{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Harris CS"],"funding":["American Cancer Society","International Society of Nurses in Genetics","National Institute of Nursing Research","NINR NIH HHS","National Cancer Institute","NCI NIH HHS"],"pagination":["51-64"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9900252"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(1)"],"pubmed_abstract":["<h4>Objectives</h4>While the gastrointestinal symptom cluster (GISC) is common in patients receiving chemotherapy, limited information is available on its underlying mechanism(s). Emerging evidence suggests a role for inflammatory processes through the actions of the nuclear factor kappa B (NF-κB) signaling pathway. This study evaluated for associations between a GISC and levels of DNA methylation for genes within this pathway.<h4>Methods</h4>Prior to their second or third cycle of chemotherapy, 1071 outpatients reported symptom occurrence using the Memorial Symptom Assessment Scale. A GISC was identified using exploratory factor analysis. Differential methylation analyses were performed in two independent samples using EPIC (<i>n</i> = 925) and 450K (<i>n</i> = 146) microarrays. Trans exp"],"journal":["Biological research for nursing"],"pubmed_title":["Gastrointestinal Symptom Cluster is Associated With Epigenetic Regulation of Lymphotoxin Beta in Oncology Patients Receiving Chemotherapy."],"pmcid":["PMC9900252"],"funding_grant_id":["T32 NR009759","Research Grant","R37 CA233774","P30 CA082103","Doctoral Degree Scholarship","NR016920","CA233774","T32 NR016920","CA134900","R01 CA134900"],"pubmed_authors":["Harris CS","Conley YP","Olshen AB","Levine JD","Hammer MJ","Miaskowski CA","Kober KM","Dhruva AA"],"additional_accession":[]},"is_claimable":false,"name":"Gastrointestinal Symptom Cluster is Associated With Epigenetic Regulation of Lymphotoxin Beta in Oncology Patients Receiving Chemotherapy.","description":"<h4>Objectives</h4>While the gastrointestinal symptom cluster (GISC) is common in patients receiving chemotherapy, limited information is available on its underlying mechanism(s). Emerging evidence suggests a role for inflammatory processes through the actions of the nuclear factor kappa B (NF-κB) signaling pathway. This study evaluated for associations between a GISC and levels of DNA methylation for genes within this pathway.<h4>Methods</h4>Prior to their second or third cycle of chemotherapy, 1071 outpatients reported symptom occurrence using the Memorial Symptom Assessment Scale. A GISC was identified using exploratory factor analysis. Differential methylation analyses were performed in two independent samples using EPIC (<i>n</i> = 925) and 450K (<i>n</i> = 146) microarrays. Trans exp","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2026-03-16T09:35:24.892Z","creation":"2025-04-05T15:54:01.006Z"},"accession":"S-EPMC9900252","cross_references":{"pubmed":["35929442"],"doi":["10.1177/10998004221115863"]}}