biostudies-literatureHarris CSAmerican Cancer SocietyInternational Society of Nurses in GeneticsNational Institute of Nursing ResearchNINR NIH HHSNational Cancer InstituteNCI NIH HHS51-64https://www.ebi.ac.uk/biostudies/studies/S-EPMC9900252biostudies-literatureUnknown25(1)<h4>Objectives</h4>While the gastrointestinal symptom cluster (GISC) is common in patients receiving chemotherapy, limited information is available on its underlying mechanism(s). Emerging evidence suggests a role for inflammatory processes through the actions of the nuclear factor kappa B (NF-κB) signaling pathway. This study evaluated for associations between a GISC and levels of DNA methylation for genes within this pathway.<h4>Methods</h4>Prior to their second or third cycle of chemotherapy, 1071 outpatients reported symptom occurrence using the Memorial Symptom Assessment Scale. A GISC was identified using exploratory factor analysis. Differential methylation analyses were performed in two independent samples using EPIC (<i>n</i> = 925) and 450K (<i>n</i> = 146) microarrays. Trans expBiological research for nursingGastrointestinal Symptom Cluster is Associated With Epigenetic Regulation of Lymphotoxin Beta in Oncology Patients Receiving Chemotherapy.PMC9900252T32 NR009759Research GrantR37 CA233774P30 CA082103Doctoral Degree ScholarshipNR016920CA233774T32 NR016920CA134900R01 CA134900Harris CSConley YPOlshen ABLevine JDHammer MJMiaskowski CAKober KMDhruva AAfalseGastrointestinal Symptom Cluster is Associated With Epigenetic Regulation of Lymphotoxin Beta in Oncology Patients Receiving Chemotherapy.<h4>Objectives</h4>While the gastrointestinal symptom cluster (GISC) is common in patients receiving chemotherapy, limited information is available on its underlying mechanism(s). Emerging evidence suggests a role for inflammatory processes through the actions of the nuclear factor kappa B (NF-κB) signaling pathway. This study evaluated for associations between a GISC and levels of DNA methylation for genes within this pathway.<h4>Methods</h4>Prior to their second or third cycle of chemotherapy, 1071 outpatients reported symptom occurrence using the Memorial Symptom Assessment Scale. A GISC was identified using exploratory factor analysis. Differential methylation analyses were performed in two independent samples using EPIC (<i>n</i> = 925) and 450K (<i>n</i> = 146) microarrays. Trans exp2023-01-01T00:00:00Z2023 Jan2026-03-16T09:35:24.892Z2025-04-05T15:54:01.006ZS-EPMC99002523592944210.1177/10998004221115863