biostudies-literatureUnknownOlsen LNIA NIH HHSNIGMS NIH HHSCircadian control of physiology and metabolism is pervasive throughout nature, with circadian disruption contributing to premature aging, neurodegenerative disease, and type 2 diabetes (Musiek et al. 2016; Panda, 2016). It has become increasingly clear that peripheral tissues, such as skeletal muscle, possess cell-autonomous clocks crucial for metabolic homeostasis (Gabriel et al. 2021). In fact, disruption of the skeletal muscle circadian rhythm results in insulin resistance, sarcomere disorganization, and muscle weakness in both vertebrates and non-vertebrates - indicating that maintenance of a functional muscle circadian rhythm provides an adaptive advantage. We and others have found that cavefish possess a disrupted central circadian rhythm and, interestingly, a skeletal muscle phenotybioRxiv : the preprint server for biology2023.01.25.525368https://www.ebi.ac.uk/biostudies/studies/S-EPMC9900830biostudies-literatureCircadian rhythm disruption is associated with skeletal muscle dysfunction within the blind Mexican Cavefish.PMC9900830R01 GM127872DP2 AG071466Olsen LKrishnan JRohner NBanks CHassan HfalseCircadian rhythm disruption is associated with skeletal muscle dysfunction within the blind Mexican Cavefish.Circadian control of physiology and metabolism is pervasive throughout nature, with circadian disruption contributing to premature aging, neurodegenerative disease, and type 2 diabetes (Musiek et al. 2016; Panda, 2016). It has become increasingly clear that peripheral tissues, such as skeletal muscle, possess cell-autonomous clocks crucial for metabolic homeostasis (Gabriel et al. 2021). In fact, disruption of the skeletal muscle circadian rhythm results in insulin resistance, sarcomere disorganization, and muscle weakness in both vertebrates and non-vertebrates - indicating that maintenance of a functional muscle circadian rhythm provides an adaptive advantage. We and others have found that cavefish possess a disrupted central circadian rhythm and, interestingly, a skeletal muscle phenoty2023-01-01T00:00:00Z2023 Jan2026-07-13T04:42:40.652Z2025-04-06T13:07:57.1ZS-EPMC99008303674768810.1101/2023.01.25.525368